Multi-modal in-vivo imaging system for small animals and small animal imaging method

Abstract

The invention discloses a multi-modal in-vivo imaging system for small animals and a small animal imaging method. The multi-modal in-vivo imaging system for small animals comprises a bracket, the bracket comprises a carrying bed system and a bracket system, the bracket system is provided with a rotary disc, and the carrying bed system is located in the axial direction of the rotary disc; the rotary disc is provided with reflector devices of an X-ray computer tomography subsystem, a positron emission tomography subsystem and an optical subsystem; the optical subsystem comprises a bio-luminescence tomography optical subsystem, a fluorescence molecular tomography optical subsystem and an optical camera, and the optical camera is mounted on the carrying bed system; the imaging view of the X-ray computer tomography subsystem, the imaging view of the positron emission tomography subsystem and the imaging view of the optical camera are at least overlapped partially; the carrying bed system further comprises an animal carrying bed, and the animal carrying bed is used for moving small animals to the overlapped region of the views.

Description

technical field [0001] The invention relates to the technical field of biomedical imaging, in particular to a multimodal small animal in vivo imaging system and a small animal imaging method thereof. Background technique [0002] In vivo imaging of small animals is a method of applying imaging to conduct qualitative and quantitative research on biological processes in vivo at the cellular and molecular levels. It uses the targeting of specific molecular probes to track and image the target, which can be used for early detection of tumors and development of new drugs. The multi-modal small animal in vivo imaging system can integrate the strengths of each system, provide fusion images, and provide more and more accurate information. [0003] Various small animal in vivo imaging techniques commonly used have their own advantages and limitations. X-ray computed tomography X-ray computed tomography, positron emission tomography, excited fluorescence molecular tomography, and bi...

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Problems solved by technology

[0005] However, at present, it mainly focuses on the dual-mode fusion equipment of X-ray computed tomography and other imaging technologies, and there are various problems in the few existing multi-modal equipment: some structures are not compact enough, just combine each The modal acquisition system is spliced ​​together; some modalities are acquired separately, and the acquisition time is long; and the positron emission tomography imaging part has not yet realized the acquisition of data by the rotating flat-plate gamma photon receiver, resulting in the need to scan separately and simultaneous imaging on the same machine and other shortcomings

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