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Space-time-compression-based dynamic fluorescence molecular tomography method for small animal

A technology of fluorescent molecular tomography and imaging methods, which is applied in the fields of analysis, diagnosis, and diagnostic signal processing using fluorescence emission. It can solve the problems of large amount of reconstruction calculations and no unique solution to the equation, so as to improve imaging accuracy and reduce the time for solving equations. , Improving the effect of imaging speed

Active Publication Date: 2017-04-19
XIDIAN UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide a small animal dynamic fluorescence molecular tomography method based on space-time compression, aiming to solve the above-mentioned problems of large amount of reconstruction calculation and no unique solution of the equation

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  • Space-time-compression-based dynamic fluorescence molecular tomography method for small animal

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[0029] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0030] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0031] Such as figure 1 As shown, the small animal dynamic fluorescence molecular tomography method based on space-time compression provided by the embodiment of the present invention includes the following steps:

[0032] S101: Acquiring small animal structure information and body surface fluorescence image sequences;

[0033] S102: Establish a system equation describing the relationship between the body surface fluorescence image sequence and the dynamic distribution of the light s...

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Abstract

The invention discloses a space-time-compression-based dynamic fluorescence molecular tomography method for a small animal. With a singular value decomposition technology, time-domain compression is carried out on a collected fluorescence image sequence; with matching filtering technology, space domain compression is carried out the fluorescence image sequence after time-domain compression; a small-animal dynamic fluorescence molecular tomography model after space domain compression is constructed; and with a least squares method, an inverse problem after the space-time compression is solved, image reconstruction is carried out, and then space-time decompression is carried out to obtain fluorescence source distribution sequences in the small animal at all collection time points. Because of the time-domain compression, the number of equations needing to be solved can be reduced; and with the space domain compression, the number of unknown numbers needing to be solved can be reduced. The reconstruction accuracy and reconstruction speed can be improved. The method has the great application value in dynamic fluorescence molecular tomography reconstruction for small animals.

Description

technical field [0001] The invention belongs to the technical field of fluorescent molecular imaging, in particular to a small animal dynamic fluorescent molecular tomographic imaging method based on space-time compression. Background technique [0002] At present, small animal fluorescence molecular tomography uses external light of a specific wavelength, such as laser, to excite the fluorescent light source in the small animal body, and uses a fluorescence acquisition device to capture the fluorescent signal on the surface of the small animal. Combined with the light transmission model, the small animal is reconstructed using mathematical methods The distribution and analysis of fluorescent light sources in the body can conduct qualitative and quantitative research on cellular and molecular levels of biological processes in vivo, and is widely used in functional gene combination proteomics, gene pathology, tumor diagnostics, cell and molecular biology science and other sub...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0071A61B5/72A61B2503/40
Inventor 陈多芳朱守平梁继民胡海虹
Owner XIDIAN UNIV
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