Fluorescence molecular tomography reconstruction method

Abstract

The invention discloses a fluorescence molecular tomography reconstruction method. The method comprises the following steps: S1, establishing a system equation for the measured data of a surface and the distribution of a fluorescent target inside an imaging object by taking the optical feature parameter and anatomical structure information of the imaging object as prior information based on an optical transmission model and a finite element theory; S2, preprocessing the system equation established in the step S1 in order that rows of a sparse matrix in the preprocessed system equation are orthogonal to each other; S3, fusing the sparse property of light source spatial distribution, selecting a plurality of rows from the system equation established in the step S1, and establishing a new coefficient matrix and a new system equation; S4, converting the new system equation established in the step S3 into a minimization problem with a constraint condition, and solving the new system equation by adopting a simultaneous algebraic reconstruction technique to obtain the three-dimensional distribution and concentration of the fluorescent target inside the imaging object. The method has the beneficial effects that the sparse property of the fluorescent target spatial distribution is fused, the prior information is increased, and the reconstruction accuracy can be increased; the system equation is preprocessed, and the rows of the coefficient matrix of the system equation are orthogonal to each other, so that the algorithm convergence can be accelerated, and the reconstruction speed is increased.

Description

technical field [0001] The invention relates to the field of excited fluorescence imaging, in particular to a reconstruction method for excited fluorescence tomography. Background technique [0002] Excited fluorescence tomography is a new optical molecular imaging technology that has emerged in recent years. It uses fluorescent probes to label imaging objects (usually living organisms such as mice and nude mice). Under the irradiation of an external excitation light source, the fluorescent probes Absorbs external excitation light to generate emission light. Outside the body of the imaging object, a high-sensitivity optical detection instrument, such as a CCD camera, is used to detect the photons transmitted outside the imaging object. Combined with the photon transport model and using mathematical methods, excited fluorescence tomography reconstructs the fluorescent target in the imaging object, so as to obtain the position and concentration information of the fluorescent ...

AI Technical Summary

Problems solved by technology

Existing excitation fluorescence tomography reconstruction based on joint algebraic iteration technology does not consider the sparse characteristics of the spatial distribution of fluorescent targets, and does not preprocess the system equations, the reconstruction accuracy and reconstruction speed need to be improved

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