Novel target feasible region extraction method and system, medium, equipment and application

Abstract

The invention belongs to the technical field of fluorescence molecular tomography, and discloses a novel target feasible region extraction method and system, a medium, equipment and an application, and the method comprises the steps: carrying out tetrahedral mesh generation of a research object through mesh generation software Amira; simulating a light transmission process by using an SP3 light transmission model, and establishing a linear relationship between measured surface light distribution and an internal fluorescence target; extracting a target feasible region in a self-adaptive manner through a multi-iteration technology; and solving the system equation by using a Tikhonov algorithm in combination with a feasible region strategy to obtain a reconstruction result. The technology can be used for fluorescent molecular tomography reconstruction, X-ray excitation tomography imaging, biological self-luminous tomography imaging and the like. Simulation experiments show that the position error is reduced to 0.71 mm, the accurate position of a fluorescent target can be obtained, the root-mean-square error value between calculated surface light distribution and measured surface light distribution can be minimum while the accurate result is obtained, and then the purpose of optimizing the reconstruction result is achieved.

Description

technical field [0001] The invention belongs to the technical field of fluorescence molecular tomography, and in particular relates to a new target feasible region extraction method, system, medium, equipment and application. Background technique [0002] At present, Fluorescence Molecular Tomography (FMT) is a very important imaging technology in optical molecular imaging technology. It noninvasively and dynamically localizes targets in three-dimensional space at the cellular and molecular levels. Therefore, fluorescence molecular tomography technology has great significance in early monitoring of diseases, drug development and treatment evaluation. The process of fluorescence molecular tomography is: the excitation light of a selected specific wavelength irradiates the organism marked with fluorescent markers. With the help of non-contact imaging system, use CCD or EMCCD to collect optical data of biological surface. By establishing a suitable mathematical model, the sp...

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Problems solved by technology

[0003] The problem existing in the prior art is that the process of solving the reverse problem is very ill-conditioned

[0004] Through the above analysis, the existing problems and defects of the existing technology are: the process of solving the reverse problem is very ill-conditioned, and choosing a good algorithm to accurately solve the reverse problem is a key issue of the prior art.

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