Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system

A technology of fluorescence molecular tomography and CT scanning, which is applied in diagnostic recording/measurement, diagnosis by using light, medical science, etc. It can solve the problems of no advantage in sensitivity and time resolution, low linearity and dynamic range, etc.

Inactive Publication Date: 2010-09-01
TIANJIN UNIV
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Problems solved by technology

[0004] The time-domain FMT implementation currently uses Time-Correlated Single PhotonCounting (TCSPC) technology, which is a discrete channel measurement technology with ultra-high sensitivity and reasonable time resolution; there is also time-gated image e

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  • Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system
  • Imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system

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Embodiment Construction

[0036] The development of a non-contact working mode imitating CT scanning is of particular significance in the realization of a time-domain FMT measurement system based on TCSPC technology: on the one hand, like all non-contact measurement modes, it can effectively simplify the measurement process and eliminate unnecessary system Errors and cumbersome coupling calibration process; on the other hand, non-contact measurement makes data acquisition flexible and diverse, and high-density acquisition and key area emphasis can be achieved by controlling the interval and range of scanning discrete angles, thus effectively making up for TCSPC technology in space. The lack of sampling density enables the system to have both ultra-sensitivity and high spatial-temporal resolution measurement performance, and then realize high-quality multi-component and multi-parameter imaging functions.

[0037] The invention is an FMT / DOT measurement system in the imitation CT scanning mode, that is, t...

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Abstract

The invention relates to the field of small animal molecular imaging, and provides an imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system with ultrasensitive and high time-space resolution measurement performances so as to realize the high-quality multi-component multi-parameter imaging function. The imitating CT scanning mode multispectral time domain fluorescence molecular tomography measuring system comprises two picosecond semiconductor lasers, an optical fiber coupler, an incident optical fiber, an imaging cavity, a rotating platform, a receiving optical fiber, a motor driving filter wheel and a detection module, wherein the two picosecond semiconductor lasers and the optical fiber coupler are used for providing wavelength ultrashort laser required, the optical fiber coupler is used for coupling two same-frequency ultrashort laser pulses of different wavelengths into a bundle of laser according to fixed time interval, the incident optical fiber is used for projecting emergent laser of two or one of both picosecond semiconductor lasers onto an object, the imaging cavity and the rotating platform are used for realizing the imitating CT scanning mode, the receiving optical fiber is used for receiving reflective or transmitted laser from the object, and the detection module is used for receiving emergent light passing through corresponding filter pieces. The invention is mainly applied to the molecular imaging of small animals.

Description

technical field [0001] The invention relates to the field of molecular imaging of small animals, in particular to a time-domain fluorescence diffusion tomography system and a time-resolved optical tomography system for molecular imaging of small animals, and in particular to a multi-spectral time-domain fluorescence molecular tomography measurement system imitating CT scanning mode. Background technique [0002] Molecular imaging is a qualitative and quantitative study of biological processes in vivo at the cellular and molecular levels using imaging methods. It uses specific molecules in the body as the mechanism for imaging contrast, and reflects the biological processes in the body through imaging at the cellular or molecular level. Physiological and pathological changes. The advantages of molecular imaging can be summarized into three points: First, molecular imaging technology can turn complex processes such as gene expression and biological signal transmission into int...

Claims

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Application Information

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IPC IPC(8): A61B5/00
CPCA61B5/0059A61B2503/40
Inventor 高峰李娇赵会娟张丽敏周仲兴张伟易茜
Owner TIANJIN UNIV
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