Tumor molecule typing method and device, terminal equipment and readable storage medium

Abstract

The invention provides a tumor molecular typing method and device, terminal equipment and a readable storage medium, and the method comprises the following steps: obtaining sequencing data of a plurality of tumor tissue samples, and calculating a copy number value; screening mutated genes in each tumor tissue sample; performing unsupervised clustering on the mutated genes to obtain a plurality of sample categories; screening genes with significant gene copy number variation among samples of each sample category, and performing unsupervised clustering to obtain a plurality of gene categories; calculating a first principal component based on the copy number variation, and determining the influence of the first principal component on the prognosis of the patient through regression analysis; and calculating copy number variation scores of the tumor tissue samples according to the influence of the first principal component on the prognosis of the patient, and classifying the samples of the sample categories according to the copy number variation scores to complete the molecular typing of the tumor. Molecular typing is carried out based on copy number variation of each gene, the resolution ratio is high, typing is accurate, and prognosis of tumor patients with different molecular types can be remarkably distinguished.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a tumor molecular typing method and device, terminal equipment and a readable storage medium. Background technique [0002] Tumors are normal cells that are developing or maturing in the human body. Under the action of certain tumorigenic factors, certain cell groups undergo excessive proliferation or abnormal differentiation to form a local mass. Compared with normal tissue cells, the metabolism of these cells does not conform to normal rules, and they will not die normally. This unrestrained growth leads to abnormal cell morphology and function, thereby destroying the structure of normal tissues and organs and affecting their functions. Tumor is a disease caused by genetic changes. Internal or external tumorigenic factors induce somatic gene mutations, and abnormal genes trigger a series of abnormal biological pathways, thereby changing the shape and function of cells. S...

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Problems solved by technology

[0004] In view of the above problems, the present invention provides a tumor molecular typing method and device, terminal equipment and a readable storage medium, which effectively solve the problem that the existing molecular typing methods have high requirements on the quality of tumor tissue and cannot distinguish between all types. Technical issues such as differences in prognosis

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