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Traditional Chinese medicine compound external gel for treating bone diseases and preparation method thereof

A gel for external use, a technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of unsatisfactory treatment effect, great pain, slow recovery, etc., and achieve the effect of uniform and delicate texture, high degree of hydration, and long-lasting effect

Pending Publication Date: 2021-05-25
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there are also related traditional Chinese medicine formulations for the treatment of fractures and fractures, they all have the problems of long course of disease, slow recovery, and great pain, and the treatment effect is not satisfactory.

Method used

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  • Traditional Chinese medicine compound external gel for treating bone diseases and preparation method thereof
  • Traditional Chinese medicine compound external gel for treating bone diseases and preparation method thereof
  • Traditional Chinese medicine compound external gel for treating bone diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] prescription:

[0061] materials use Dosage (%) Chinese herbal extract Main drug 10.0 HEC gel matrix 8.0 glycerin moisturizer 5.0 15% ethanol Fat-soluble drug solvent 7.0 Ethylparaben preservative 0.1 citric acid crosslinking agent 5.0 Menthol Penetration enhancer 3.0 purified water water soluble drug solvent 61.9

[0062] Among the main ingredients, Panax notoginseng extract 3.0%, Salvia miltiorrhiza extract 0.5%, Safflower extract 2.0%, Wood beetle extract 1.0%, Interstitial extract 1.0%, Myrrh extract 1.0% and Spatholobus extract 1.5%.

[0063] The specific process is:

[0064] 1) Add HEC in the prescription to purified water (the amount of purified water is 80% of the total amount of purified water in the prescription), stir continuously at 60°C for 1 hour to make it fully swell, then add 5.0% citric acid, and continue stirring After 2h, HEC-citric acid cross-linking solution was obt...

Embodiment 2

[0068] prescription:

[0069] materials use Dosage (%) drug Main drug 16.0 HPMC gel matrix 10.0 Sorbitol moisturizer 10.0 15% ethanol Fat-soluble drug solvent 10.0 Ethylparaben preservative 0.1 Glyoxal crosslinking agent 5.0 Menthol Penetration enhancer 1.9 purified water water soluble drug solvent 47.0

[0070] Among the main ingredients, Panax notoginseng extract 5.0%, Salvia miltiorrhiza extract 0.5%, Safflower extract 3.0%, Wood beetle extract 2.0%, Intermittent extract 1.5%, Myrrh extract 2.0% and Spatholobus extract 2.0%.

[0071] The specific process is:

[0072] 1) Add HPMC in the prescription to purified water (the amount of purified water is 80% of the total amount of purified water in the prescription), stir continuously at 65°C for 1.5 hours to make it fully swell, and then add 5.0% glyoxal, Stirring was continued for 2.5 h to obtain a HPMC-glyoxal cross-linking solution.

[0073] ...

Embodiment 3

[0076] prescription:

[0077] materials use Dosage (%) drug Main drug 8.0 HPC gel matrix 5.0 Propylene Glycol moisturizer 15.0 20% ethanol Fat-soluble drug solvent 5.0 Butylparaben preservative 0.1 lignin crosslinking agent 10.0 Camphor Penetration enhancer 5.0 purified water water soluble drug solvent 51.9

[0078] Among the main ingredients, Panax notoginseng extract 2.0%, Salvia miltiorrhiza extract 0.5%, Safflower extract 1.0%, Wood beetle extract 1.0%, Intermittent extract 1.5%, Myrrh extract 1.0% and Spatholobus extract 1.0%.

[0079] The specific process is:

[0080] 1) Add HPC in the prescription to purified water (the amount of purified water is 80% of the total amount of purified water in the prescription), stir continuously for 1 hour at 63°C to make it fully swell, then add 10.0% lignin, and continue stirring 2h to obtain the HPC-lignin cross-linking solution.

[0081] 2) Ultrasoni...

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Abstract

The invention relates to a traditional Chinese medicine compound external gel for treating bone diseases and a preparation method thereof, the traditional Chinese medicine compound external gel is prepared from a traditional Chinese medicine extract composed of pseudo-ginseng, safflower carthamus, red sage root and the like, a hydrophilic gel matrix and other auxiliary materials, and the drug loading capacity is 8-16%. Based on different characteristics of the medicines, the gel is prepared by the preparation method, solves the problems that the medicines such as the pseudo-ginseng, the safflower carthamus and the red sage root are unstable in chemical property, easy to oxidize and deteriorate, difficult to dissolve in water, have a certain stimulation effect and the like, and has the effects of clearing and activating the channels and collaterals, dispersing blood stasis and dissipating binds, relieving swelling and pain and promoting fracture healing; the traditional Chinese medicine compound external gel is short in treatment period, low in cost, simple in preparation process, efficient, safe and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a traditional Chinese medicine compound gel for external use for treating bone diseases and a preparation method thereof. Background technique [0002] Bone disease has become an important disease that seriously affects human health. With the advent of my country's elderly society, the incidence of various bone-related diseases such as fractures and osteoporosis is also increasing year by year. Osteoporosis (osteoporosis) is a metabolic bone disease with systemic characteristics, characterized by loss of bone mass and destruction of bone microstructure. When the organic and inorganic matter of the bone is lost, the density of the bone will decrease, and the loss of the inorganic and organic matter in the matrix will weaken the compressive load capacity of the bone, which is the main cause of osteoporosis. Patients with osteoporosis have decreased bone strength and increased fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/06A61K47/38A61K47/10A61K47/12A61K47/08A61K47/30A61P19/08A61P29/00A61K35/64
CPCA61K9/0014A61K9/06A61K35/64A61K36/185A61K36/258A61K36/286A61K36/328A61K36/486A61K36/537A61K47/08A61K47/10A61K47/12A61K47/30A61K47/38A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P19/08A61P29/00A61K2300/00
Inventor 杨建宏郭珏铄买亚萍余蕊李莉侯延辉
Owner NINGXIA MEDICAL UNIV
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