An ion filter device and method

Abstract

The invention relates to an ion filtering device and method, which is characterized in that it comprises a casing, a pulse high-voltage power supply and a digital delay pulse generator, and the casing is provided with a time-of-flight mass spectrometry acceleration device, a deceleration device, a detector and an electrostatic focusing lens ; Located on the initial flight axis of the ion to be selected, the top of the housing is fixedly arranged for the time-of-flight mass spectrometer acceleration device for accelerating the ion to be selected; the bottom of the housing is fixedly provided with the deceleration device and detector and an electrostatic focusing lens; the time-of-flight mass spectrometer acceleration device and deceleration device are respectively connected to the pulse high-voltage power supply; the pulse high-voltage power supply is also connected to the digital delay pulse generator, and the present invention can be widely used in the field of mass spectrometry analysis.

Description

technical field [0001] The invention relates to an ion filtering device and method, belonging to the field of mass spectrometry. Background technique [0002] Ion filtration (mass filtration, mass selection or mass selection) is an important method in the field of mass spectrometry. It uses electric field, magnetic field or electromagnetic field to generate ion packets containing a series of different charge-to-mass ratios from the ion source. Ions with specific charge-to-mass ratios are purposely selected (ions with other charge-to-mass ratios are filtered) for targeted characterization, such as collision-induced dissociation and ion-molecular reactions. [0003] Quadrupoles are the most commonly used ion filters and are widely used in mass spectrometers such as multiple quadrupoles and quadrupole-time-of-flight. However, the quadrupole has the following obvious disadvantages: 1) The mass selection pass rate of the quadrupole (that is, the number of ions with a specific ch...

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Problems solved by technology

However, the quadrupole has the following obvious disadvantages: 1) The mass selection pass rate of the quadrupole (that is, the number of ions with a specific charge-to-mass ratio after mass selection / the number of corresponding ions before mass selection×100%) is related to the ion mass , as the ion mass becomes larger, the mass selection pass rate will be significantly reduced. For example, for ions of 1000 amu, the mass selection pass rate of the quadrupole is less than 1%, so the quadrupole is mainly used for ion filtration or analysis within 2000 amu; 2 ) Quadrupole processing and assembly precision requirements are extremely high. For example, the parallelism of the four electrode rods is required to be around 2 μm, which can only be produced by a handful of companies; 3) Quadrupole quality selection requires high-voltage RF power supply (RF voltage is proportional to the mass of ions), and the impedance matching of the radio frequency circuit also has certain barriers

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