Synthesis method of combined buprofezin

Abstract

The invention discloses a synthesis method of combined buprofezin, relates to the technical field of synthesis methods of buprofezin, and aims to solve the problem that carbonyl chloride crop organic intermediates are usually used for reaction in the existing synthesis process of combined buprofezin, but carbonyl chloride is a violent suffocating poison gas and can cause harm to human bodies after being inhaled by people. The synthesis method comprises the following steps of: adding N-methylaniline and formic acid into a reaction kettle to prepare N-methyl formyl amine, adding the prepared N-methyl formyl amine, carbon tetrachloride and benzoyl peroxide into a distillation kettle, then introducing chlorine gas to prepare an N-chloromethyl-N-phenyl carbamoyl chloride solution, then preparing tert-butyl isothiocyanate preparing an N-tert-butyl-N'-isopropyl thiourea solution, and adding the prepared N-chloromethyl-N-phenyl carbamoyl chloride solution, tert-butyl isothiocyanate, acetone, dimethyl formamide and potassium hydroxide into a reaction kettle for reaction to obtain buprofezin crystals.

Description

technical field [0001] The invention relates to the technical field of synthesis methods of buprofezin, in particular to a synthesis method of combined buprofezin. Background technique [0002] Buprofezin, also known as buprofezin, is an insect growth regulator insecticide. It is a selective insect growth regulator that can inhibit the synthesis of insect chitin. It has strong selectivity to pests, high lethality, and long residual effect. , low toxicity, etc. It is mainly used for pest control of rice, fruit trees, tea trees, vegetables and other crops. It has persistent larvicidal activity against Coleoptera, some Homoptera and Acarina, thus effectively protecting crops. [0003] However, the existing combined buprofezin usually uses carbonyl chloride crop organic intermediates to react during the synthesis process, and carbonyl chloride is a severe suffocating poisonous gas, which will cause harm to the human body when people inhale it, so There is an urgent need for a s...

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Problems solved by technology

[0004] The purpose of the present invention is to provide a synthetic method of combined buprofezin, to solve the problem that the existing combined buprofezin proposed in the above background technology usually uses carbonyl chloride crop organic intermediates in the process of synthesis. reaction, and carbonyl chloride is a severe suffocating gas, which will cause harm to the human body when inhaled

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