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Methods and compositions for treating immune checkpoint inhibitor associated colitis

An immune checkpoint, colitis technology with applications in molecular biology and medicine

Pending Publication Date: 2022-01-07
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Treatment with ICIs targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), and programmed cell death ligand 1 (PD-L1) was associated with enhanced T cell activation is associated with potent antitumor immune responses, but treatment may be associated with serious immune-related adverse events (irAEs) in some patients

Method used

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  • Methods and compositions for treating immune checkpoint inhibitor associated colitis
  • Methods and compositions for treating immune checkpoint inhibitor associated colitis
  • Methods and compositions for treating immune checkpoint inhibitor associated colitis

Examples

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Embodiment 1

[0176] Example 1 Fecal microbiota transplantation in the treatment of refractory immune checkpoint inhibitor-associated colitis

[0177] The inventors report the first case series of successful treatment of immune checkpoint inhibitor (ICI)-associated colitis with fecal microbiota transplantation, reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T cells within the colonic mucosa. These preliminary data provide evidence that modulating the gut microbiome can eliminate ICI-associated colitis.

[0178] The inventors sought to determine the impact of treatment with FMT from healthy donors in patients with refractory ICI-associated colitis and enrolled two patients in this regimen between June 2017 and January 2018 (CIND17-0036, CIND17-0058). The clinical course of the two patients was image 3 -5 for further details. The first patient, a 50-year-old woman with high-grade metastatic urothelial carcinoma refractory to standard chemother...

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Abstract

Described herein are methods and compositions for treating immune checkpoint inhibitor (ICI)-associated colitis in a subject comprising administering fecal matter from a healthy donor to the subject. Further aspects of the disclosure relate to a method of treating immune checkpoint inhibitor (ICI)-associated colitis in a subject comprising administering to the subject a composition comprising at least one isolated or purified population of bacteria belonging to one or more of the genera Escherichia, Akkermansia, Bacteroides, Lachnospiraceae, Blautia, Tyzzerella, Bifidobacterium, Streptococcus, Colinsella, and Fusicatenibacter.

Description

[0001] Related Application Cross Reference [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 793,085, filed January 16, 2019, the entire contents of which are hereby incorporated by reference. [0003] Statement of Government Support [0004] This invention was made with Government support under Numbers CA219896 and HL124112 awarded by the National Institutes of Health. The government has certain rights in this invention. [0005] Background of the invention 1. Technical field [0006] The present invention relates to the fields of molecular biology and medicine. 2. Background technology [0007] Immunotherapy has transformed the field of oncology, improving long-term survival for patients with multiple cancer types. Treatment with ICIs targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), and programmed cell death ligand 1 (PD-L1) was associated with enhanced T cell activation ...

Claims

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Application Information

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IPC IPC(8): A61K35/741A61K35/745A61K35/744A61P1/00A61P29/00A23L33/135A23L2/38
CPCA61K35/37A23L33/135A61K35/741Y02A50/30A61P37/02
Inventor 詹尼弗·A·沃戈王莺红罗伯特·珍克
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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