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Method and device for determining changes in retinal and/or brain temperature

A technology of retina and equipment, applied in the field of arrangement of retinal pigment epithelial cells, can solve the problems of signal phase shift, loss of specific peak information, phase shift is not an accurate temperature index, etc., and achieve effective treatment

Pending Publication Date: 2022-02-08
玛库激光公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A disadvantage of this method is that subsequent responses combine and phase shift may not be an accurate indicator of temperature
In addition, since the response trace resembles a sine wave, specific peak information is lost, and a slight change in the amplitude ratio of different signal components has a noticeable effect on the overall phase shift of the signal

Method used

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  • Method and device for determining changes in retinal and/or brain temperature
  • Method and device for determining changes in retinal and/or brain temperature
  • Method and device for determining changes in retinal and/or brain temperature

Examples

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Embodiment Construction

[0027] The object of the invention can be achieved, for example, by focusing stimulating light on the retina and recording the FERG signal with a system comprising electrodes positioned on the patient.

[0028] In the following paragraphs, the solution of one embodiment of the invention is described. In this exemplary embodiment, the FERG response is obtained prior to the temperature change, and the response is processed to produce a single ERG response with an increased signal-to-noise ratio (e.g., a high signal-to-noise ratio, or, for example, a higher signal-to-noise ratio relative to the individual flash responses Compare). In one embodiment of the invention, multiple (e.g., tens or hundreds) of response signals are obtained, and then digital signal processing techniques such as digital filtering, matched filtering, and signal averaging are used to reduce noise and extract data from, for example, Various sources such as eye blinks, eye movements, and muscle activity remov...

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PUM

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Abstract

In the solution of the invention at least one an electrical response signal from a retina is acquired in a first temperature, at least one electrical response signal from the retina is acquired in at least a second temperature, the second temperature being different than the first temperature. At least the electrical response signal acquired in the second temperature is transformed with a plurality of different transformation parameter values resulting a plurality of different transformed signals. The different transformed signals of the electrical response signal in the second temperature are compared to the electrical response signal and / or the transformed signals acquired from the retina in the first temperature. The transformed electrical response signal which produces the highest similarity measure with the electrical response signal and / or transformed signal acquired from the retina in the first temperature is selected. The transformation parameter value or parameter values of the selected transformed signal is converted to a temperature, temperature difference estimate and / or temperature dependent indicator between the first temperature and the second temperature.

Description

technical field [0001] The present invention relates to a device and method for determining changes in retinal and / or brain temperature. Furthermore, the invention relates to an arrangement for controlling a heating device for heating an area of ​​retinal tissue and in particular an area of ​​interest of the retinal pigment epithelium inside the eye. [0002] The invention is to be applied, for example, in the field of medical interventions, where for example by electromagnetic radiation, for example by laser or by light from light-emitting diodes (LEDs), an increase in temperature can be generated and can be induced simultaneously in the retina of the eye as well as in the retinal pigment epithelium monitor and control the temperature rise. Background technique [0003] There is strong scientific evidence that heating the retinal tissue or retinal pigment epithelium (RPE) at the back of the eye has a range of beneficial effects on unhealthy RPE, such as increased productio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/008A61B5/398A61B3/10A61B3/12A61B3/14A61B5/01A61N5/06
CPCA61F9/008A61F2009/00844A61F2009/00863A61B3/10A61B5/01A61B3/12A61N5/0613A61N2005/0651A61N2005/0626A61F9/0079A61N5/0625A61B5/398A61B5/6821A61N1/36046A61N5/1017
Inventor 奥西·凯科宁泰穆·图鲁宁玛丽亚·皮特卡宁阿里·科斯凯莱宁
Owner 玛库激光公司
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