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Intestinal flora capsule and preparation method thereof

A technology of intestinal flora and capsules, applied in capsule delivery, pharmaceutical formulations, medical raw materials derived from bacteria, etc., can solve the problem that the quality of fecal bacteria is difficult to guarantee, the FMT technology is limited by the way of digestive endoscope catheterization and transplantation, and the patient compliance is poor. And other issues

Pending Publication Date: 2022-02-15
THE AFFILIATED HOSPITAL OF MEDICAL SCHOOL NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The invention solves the problems that the existing FMT technology is limited by the transplantation approach of digestive endoscope catheterization, it is difficult to popularize and popularize, the patient compliance is poor, and it is difficult to carry out in grass-roots hospitals; in addition, the traditional intestinal flora extraction method, operation process and standard Not uniform, difficult to guarantee the quality of fecal bacteria

Method used

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  • Intestinal flora capsule and preparation method thereof

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Effect test

Embodiment 1

[0042] see figure 1, start the excrement processing instrument 100, weigh 80 grams of excrement, and put it into the excrement collection bottle 120. Press the "deodorization" button to start the deodorization device. Press the "water injection" key, the first power pump 110 will press the physiological saline in the water supply tank 130 into the feces collection bottle 120, and inject 650 ml of physiological saline. Press the "stirring" key, and the stirring device at the upper end of the feces collection bottle 120 starts to stir, and the feces and physiological saline are mixed. Press the "filter" button, the diluted feces enters the filter 140 through the pipeline, and the filter 140 is provided with 5 filter bottles, and each filter bottle is sequentially provided with diameters of 1.5mm, 1mm, 0.5mm, 0.15mm, 0.1 mm filter. The filtered fecal bacteria liquid is temporarily collected in the buffer bottle 150 . Press the "subpackage" key, the second power pump 160 start...

Embodiment 2

[0048] see figure 1 , start the excrement processing instrument 100, weigh 150 grams of excrement, and put it into the excrement collection bottle 120. Press the "deodorization" button to start the deodorization device. Press the "water injection" key, the first power pump 110 will press the physiological saline in the water supply tank 130 into the feces collection bottle 120, and inject 850 ml of physiological saline. Press the "stirring" key, and the stirring device at the upper end of the feces collection bottle 120 starts to stir, and the feces and physiological saline are mixed. Press the "filter" button, the diluted feces enters the filter 140 through the pipeline, and the filter 140 is provided with 5 filter bottles, and each filter bottle is sequentially provided with diameters of 1.5mm, 1mm, 0.5mm, 0.15mm, 0.1 mm filter. The filtered fecal bacteria liquid is temporarily collected in the buffer bottle 150 . Press the "subpackage" key, the second power pump 160 sta...

Embodiment 3

[0054] see figure 1 , start the excrement processing instrument 100, weigh 180 grams of excrement, and put it into the excrement collection bottle 120. Press the "deodorization" button to start the deodorization device. Press the "water injection" key, the first power pump 110 will press the physiological saline in the water supply tank 130 into the feces collection bottle 120, and inject 850 ml of physiological saline. Press the "stirring" key, and the stirring device at the upper end of the feces collection bottle 120 starts to stir, and the feces and physiological saline are mixed. Press the "filter" button, the diluted feces enters the filter 140 through the pipeline, and the filter 140 is provided with 5 filter bottles, and each filter bottle is sequentially provided with diameters of 1.5mm, 1mm, 0.5mm, 0.15mm, 0.1 mm filter. The filtered fecal bacteria liquid is temporarily collected in the buffer bottle 150 . Press the "subpackage" key, the second power pump 160 sta...

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Abstract

The invention provides an intestinal flora capsule and a preparation method thereof. The preparation method comprises the following steps: S10, preparing liquid; S20, centrifuging the fecal bacteria liquid, removing a supernate, retaining turbid liquid, and adding normal saline into the turbid liquid to obtain washing bacteria liquid; S30, mixing, centrifuging and washing the bacterial liquid for at least one time to obtain a purified bacterial liquid; and S40, preparing the purified bacterial liquid into powder, and filling the powder into capsules to prepare the intestinal flora capsules. According to the invention, the activity and quantity of intestinal flora can be maintained, the traditional endoscopic catheterization transplantation approach is improved, and a capsule oral administration mode is adopted, so that the coprophilous fungus transplantation approach is more convenient, and meanwhile, the treatment effect can also be ensured.

Description

technical field [0001] The invention relates to the technical field of fecal bacteria transplantation, in particular to an intestinal flora capsule and a preparation method thereof. Background technique [0002] There are as many as 100 trillion bacteria in the human intestinal tract, which is called the organ of forgetting. Factors such as the environment, diet structure, and the use of antibiotics all affect the state of the intestinal flora. Decreased flora diversity or changes in flora species will affect the body's immune regulation and substance metabolism, and intestinal flora dysbiosis is related to the occurrence of various diseases. At present, there are three main ways to rebuild intestinal flora: antibiotics, probiotics and fecal microbiota transplantation (FMT). FMT is the transplantation of gut microbiota from a screened healthy donor to a recipient to restore the disrupted gut microbiota by establishing a stable, complex microflora to correct the imbalance. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K9/48A61K47/10A61K47/36A61K47/26A61K47/46A61K47/18A61P1/00C12N1/02
CPCA61K35/74A61K9/4808A61P1/00C12N1/02A61K9/4858A61K9/4866A61K9/4875
Inventor 周玉平杨冬雪杨萍邓凯莉叶国良
Owner THE AFFILIATED HOSPITAL OF MEDICAL SCHOOL NINGBO UNIV
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