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Application of gliquidone in preparation of medicine for treating ulcerative colitis

A technology for ulcerative colitis and glitazone, applied in the field of medicine, can solve problems such as ulcerative colitis that has not been seen with glitazone, and achieve the effect of improving intestinal damage and relieving disease symptoms

Pending Publication Date: 2022-03-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of gliquidone in the treatment of ulcerative colitis

Method used

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  • Application of gliquidone in preparation of medicine for treating ulcerative colitis
  • Application of gliquidone in preparation of medicine for treating ulcerative colitis
  • Application of gliquidone in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Experimental animals and reagents

[0022] Animals: 24 SPF grade male Sprague-Dawley rats, 6-8 weeks old, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Zhejiang) 2019-0001), and all experimental rats were Raised under laboratory standard feeding conditions, temperature 24±2°C, humidity 50±5%, raised under 12h / 12h day and night cycle conditions for one week, so that they can fully adapt to the environment.

[0023] Drugs and reagents: Dextran sodium sulfate (DSS, MW: 40KD) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.; Gliquidone (Glq, CAS No.: 33342-05-1) was purchased from MedChem, USA Express Company; creatinine (CRE) and blood urea nitrogen (BUN) assay kits were purchased from Nanjing Jiancheng Bioengineering Institute.

[0024] Instruments and equipment: Multifunctional microplate reader (Tecan Infinite 200Pro, Switzerland), microplate constant temperature shaker (Hangzhou Aosheng ...

Embodiment 2

[0049] A tablet for treating ulcerative colitis, the active ingredient is gliquidone, and the auxiliary material is a conventional auxiliary material for the tablet.

[0050] The invention discloses a capsule for treating ulcerative colitis, the active ingredient is gliquidone, and the auxiliary material is the conventional auxiliary material of the capsule.

[0051] An injection for treating ulcerative colitis, the active ingredient is gliquidone, and the auxiliary materials are conventional auxiliary materials for injections.

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Abstract

The invention discloses an application of gliquidone in preparation of a medicine for treating ulcerative colitis. It is found that gliquidone can effectively relieve disease symptoms of ulcerative colitis model rats and effectively improve intestinal injuries. Therefore, the gliquidone has the prospect of being developed into the medicine for treating ulcerative colitis.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known compounds, in particular to the application of gliquidone for preparing medicine for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (Ulcerative colitis, UC) is a chronic non-specific inflammatory disease, its clinical manifestations are complex, endoscopic and pathological manifestations are not specific, so the diagnosis is difficult. Patients often have symptoms such as abdominal pain, diarrhea, and blood in the stool. If not treated in time, it may cause complications such as anemia, perforation, and cancer. It often involves the mucosa and submucosa of the colorectum, and it is distributed continuously and diffusely, and the course of the disease is long. , protracted and difficult to heal, has been listed as one of the modern refractory diseases. In recent years, the incidence of inflammatory bowel disease worldwide has been i...

Claims

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Application Information

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IPC IPC(8): A61K31/64A61P1/04A61P29/00
CPCA61K31/64A61P1/04A61P29/00
Inventor 张培唐恬许风国杨柳张尊建
Owner CHINA PHARM UNIV
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