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Veterinary vaccine diluent with immunological enhancement function as well as preparation method and application of veterinary vaccine diluent

An immune-enhancing and diluent technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of complex emulsion preparation process and troublesome clinical use, and achieve good immune enhancement. effect, increase antibody titer, increase antibody level

Pending Publication Date: 2022-04-12
WEST ANHUI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previously, it was reported in the literature that using emulsion as a vaccine diluent can significantly increase the antibody titer, but the preparation process of the emulsion is complicated and the clinical use is relatively troublesome.

Method used

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  • Veterinary vaccine diluent with immunological enhancement function as well as preparation method and application of veterinary vaccine diluent
  • Veterinary vaccine diluent with immunological enhancement function as well as preparation method and application of veterinary vaccine diluent
  • Veterinary vaccine diluent with immunological enhancement function as well as preparation method and application of veterinary vaccine diluent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 prepares vaccine diluent and vaccine

[0023] Weigh 25 mg of Dendrobium officinale polysaccharide, dilute it to 100 ml with normal saline, sonicate for 30 minutes, dissolve, and then filter and sterilize with a sterile microporous membrane with a pore size of 0.22 μm to prepare a vaccine dilution. Before use, add a 1:100 vaccine diluent to the vaccine antigen according to the vaccine instruction manual (that is, the vaccine antigen is diluted 100 times by the diluent).

Embodiment 2

[0024] Embodiment 2 prepares vaccine diluent and vaccine

[0025] Weigh 25 mg of Dendrobium officinale polysaccharide, dilute it to 100 ml with normal saline, sonicate for 30 minutes, dissolve, and then filter and sterilize with a sterile microporous membrane with a pore size of 0.22 μm to prepare a vaccine dilution. Before use, add a 1:1000 vaccine diluent to the vaccine antigen according to the vaccine instruction manual (that is, the vaccine antigen is diluted 1000 times by the diluent).

Embodiment 3

[0026] Embodiment 3 prepares vaccine diluent and vaccine

[0027] Weigh 25 mg of Dendrobium officinale polysaccharide, dilute it to 100 ml with normal saline, sonicate for 30 minutes, dissolve, and then filter and sterilize with a sterile microporous membrane with a pore size of 0.22 μm to prepare a vaccine dilution. Before use, add a 1:1000 vaccine diluent to the vaccine antigen according to the vaccine instruction manual (that is, the vaccine antigen is diluted 500 times by the diluent)

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Abstract

The invention discloses a veterinary vaccine diluent with an immunological enhancement effect, which comprises dendrobium officinale polysaccharide and normal saline, and m: v is (1: 10000)-(1: 2). The preparation process comprises the following steps: weighing the dendrobium officinale polysaccharide and the normal saline according to the mass volume ratio; and dissolving the dendrobium officinale polysaccharide in normal saline, fixing the volume, and filtering and sterilizing by using a sterile microfiltration membrane to obtain the vaccine diluent. The veterinary vaccine diluent and the powder inactivated antigen which are mixed in any proportion are mixed to prepare the vaccine, and generation of antibodies is promoted.

Description

technical field [0001] The invention relates to the technical field of veterinary vaccines, in particular to a diluent of veterinary vaccines with immune enhancing effect and its preparation method and application. Background technique [0002] In recent years, various infectious diseases have continued to spread among livestock and poultry, posing a serious threat to the healthy development of the livestock and poultry breeding industry. Vaccination is the most effective means to prevent various infectious diseases of livestock and poultry. However, due to problems such as the health of livestock and poultry, the environment, and the characteristics of vaccine antigens, the host cannot produce sufficient levels of antibodies after vaccination. cause large economic losses. In order to solve this problem and deal with sudden infectious diseases, it is necessary to carry out research on antigen diluents on the basis of research on the vaccine itself. [0003] The antigen dil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K47/36A61K47/02A61K9/08A61P37/04
Inventor 何燕飞赵勇佘德勇蒋平徐光沛
Owner WEST ANHUI UNIV
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