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Method for evaluating consistency of traditional extraction method and modern extraction method of traditional Chinese medicine compound preparation

An extraction method and technology of compound preparations, which are applied in the field of evaluating the consistency of traditional extraction methods and modern extraction methods of traditional Chinese medicine compound preparations

Pending Publication Date: 2022-04-15
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, this is not in line with the ancient requirements of the classic Chinese medicine compound preparations

Method used

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  • Method for evaluating consistency of traditional extraction method and modern extraction method of traditional Chinese medicine compound preparation
  • Method for evaluating consistency of traditional extraction method and modern extraction method of traditional Chinese medicine compound preparation
  • Method for evaluating consistency of traditional extraction method and modern extraction method of traditional Chinese medicine compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1 Consistency Evaluation of Xiaoxuming Decoction Traditional Extraction Method and Modern Extraction Method

[0076] 1. Determine the evaluation object

[0077] In this embodiment, Xiaoxuming Decoction (XXMT) recorded in the "Ancient Classic Prescription Catalog (First Batch)" is taken as an example. Ginseng, scutellaria baicalensis, osmanthus, licorice, peony, chuanxiong, almonds, one or two each, aconite, one and a half of windproof, five liang of ginger; the right twelve flavors, Jue, take one bucket and two liters of water, first boil the ephedra for three times, remove the foam, and boil all the medicines in it for three liters. Based on the medical records of past dynasties, according to the key information of ancient classic prescriptions and ancient records issued by the state, XXMT benchmark samples and modern extraction samples were prepared on the basis of determining the raw materials, medicinal parts, processing specifications, and converted doses...

Embodiment 2

[0153] Example 2 Consistency evaluation of ancient and modern extraction processes of Danggui Buxue Decoction

[0154] 1. Determine the evaluation object

[0155] This embodiment takes Danggui Buxue Decoction (DBT) recorded in the "Ancient Classic Prescription Catalog (First Batch)" as an example. Money (washed with wine), upper piece of mouth, all in one serving. Two cups of water, fry until one cup is removed, remove the residue, serve warm, before eating. Based on the medical records of past dynasties, according to the key information of ancient classic prescriptions issued by the state and the records of ancient books, the benchmark samples of DBT and the samples extracted by modern technology are prepared on the basis of determining the raw materials, medicinal parts, processing specifications, and converted doses. , the specific method is as follows:

[0156] (1) Preparation of reference samples (traditional extraction method): Weigh the doses of Astragalus membranace...

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Abstract

The invention belongs to the field of evaluation methods, and provides a method for evaluating the consistency of a traditional extraction method and a modern extraction method of a traditional Chinese medicine compound preparation. According to the method, the reference correlation degree is calculated based on the relative deviation value, the value threshold of the reference correlation degree is within the interval of [-infinity, 1], when the relative deviation value is 0, the reference correlation degree is 100%, and at the moment, the quality of a modern extracted sample is completely consistent with that of a reference sample. Therefore, compared with the relative deviation value, the reference correlation degree can more intuitively and clearly represent the quality difference between the modern extracted sample and the reference sample. The subjective weighting method and the objective weighting method are combined for comprehensive evaluation, so that the subjective intention of a decision maker can be reflected, actual data are not separated, and the final weighting result is more persuasive. The evaluation method provided by the invention solves the problem of conversion between a conventional extraction method and a modern extraction method of a classic famous prescription at present, and ensures that the determined modern extraction method not only can meet the quality requirement of a reference sample, but also can meet the production conditions of a modern process.

Description

technical field [0001] The invention relates to the technical field of evaluation methods, in particular to a method for evaluating the consistency between a traditional extraction method and a modern extraction method for a compound preparation of traditional Chinese medicine. Background technique [0002] The "Law of the People's Republic of China on Traditional Chinese Medicine" passed in 2016 states that only non-clinical safety research data can be provided when applying for a drug approval number for classic famous prescription products. In 2018, the State Administration of Traditional Chinese Medicine released the catalog of ancient classic famous prescriptions (the first batch), which included a total of 100 prescriptions, and listed in detail 6 items of classic famous prescriptions, including the name, source, prescription, preparation method, usage and dosage form. content. The policy encourages and supports the research and development of ancient classic prescrip...

Claims

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Application Information

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IPC IPC(8): G16H20/10G16H70/40G06K9/62
CPCG06Q10/06393G06Q10/06395G16H20/10G16H70/40G16H20/90
Inventor 张爱军赵军宁代珊李帅朱红梅曾瑾毛九州
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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