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Application of uncaria rhynchophylla active compound in preparation of medicine for preventing and/or treating mental disorder diseases

A technology of mental disorders and compounds, which is applied in the field of medical applications, can solve the problems of traumatic memory fading, etc., and achieve the effect of enhancing learning memory and promoting traumatic memory fading

Active Publication Date: 2022-04-29
ACADEMY OF MILITARY MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently there are no drugs based on promoting the extinction of traumatic memories

Method used

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  • Application of uncaria rhynchophylla active compound in preparation of medicine for preventing and/or treating mental disorder diseases
  • Application of uncaria rhynchophylla active compound in preparation of medicine for preventing and/or treating mental disorder diseases
  • Application of uncaria rhynchophylla active compound in preparation of medicine for preventing and/or treating mental disorder diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1.1 Reagents and materials used in the experiment:

[0045] C57 mice, male, 4-6 weeks old, body weight 18±2g, clean grade, SPEF (Beijing) Biotechnology Co., Ltd. Animals were kept at ambient temperature (25±1° C.), humidity (50±5%), free to eat and drink, and light / dark for 12 hours each day.

[0046] Rhynchophylline and isorhynchophylline were provided by Kunming Institute of Botany, Chinese Academy of Sciences.

[0047] 1.2 Experimental process

[0048] After the mice experience traumatic events, they can show fear behavior to the environment and cues related to the traumatic event, and the fear behavior of the animals is significantly reduced after administration of rhynchophylline and isorhynchophylline.

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Abstract

The invention provides application of an uncaria active compound in preparation of a medicine for preventing and / or treating mental disorder diseases, and relates to the technical field of medical application. The mental disorder diseases comprise neurological and mental disorders caused by traumatic memory. The uncaria active compound disclosed by the invention can comprise rhynchophylline, isorhynchophylline, and derivatives, isomers and the like obtained by modifying molecular structures of the active compounds. The active compound provided by the invention can promote fading of wound memory, and has prevention and alleviation effects on neuropsychiatric disorders (such as post-traumatic stress disorder and phobia) and the like caused by the wound memory.

Description

technical field [0001] The invention relates to the technical field of medical applications, in particular to the application of active compounds of Uncaria uncaria in the preparation of drugs for preventing and / or treating mental disorders. Background technique [0002] Traumatic events include natural disasters, accidents (such as traffic accidents, terrorist incidents), wars, and military operations that can cause traumatic memories. Abnormal enhancement or extinction disorders of memories related to traumatic events can lead to serious neuropsychiatric disorders such as post-traumatic stress disorder, anxiety, fear, and depression. Traumatic events such as rescue and disaster relief and military operations lead to cognitive impairment and symptoms of mental disorders, which can seriously affect combat effectiveness and task completion. The mechanism of traumatic memory, a psychopathological phenomenon, is very complicated. [0003] At present, treatment methods such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/438A61K36/74A61P25/28A61P25/24A61P25/22A61P25/00
CPCA61K31/438A61K36/74A61P25/28A61P25/24A61P25/22A61P25/00A61K2300/00Y02A50/30
Inventor 周文霞黄晏赵勤实张永祥彭丽艳王陈周浩锋于琪王新悦王子元
Owner ACADEMY OF MILITARY MEDICAL SCI
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