Micro-needle patch

A technology of microneedle sticking and microneedle, which is applied in the field of microneedle, can solve problems such as chimeric instability and skin extrusion, and achieve the effects of improving comfort and aesthetics, enhancing adhesion, and ensuring the effect of drug delivery

Active Publication Date: 2022-05-06
YOUWE ZHUHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a microneedle patch, which solves the technical problems in the prior art that the microneedles are not stable in the skin after being pierced into the skin, and are easy to be squeezed out by the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] This embodiment provides a microneedle patch, which includes a base layer and at least one microneedle 4, and at least one microneedle 4 is arranged at the bottom of the base layer. The microneedles 4 themselves carry the drug ingredients and can dissolve in the skin.

[0056] Further, refer to Figure 1-13As shown, the microneedle 4 includes a microneedle body 41 . In the vertical direction, the microneedle body 41 sequentially includes a needle tip 411 , a middle portion 412 and a needle seat 413 . The pin holder 413 is connected to the base layer. The circumferential direction of the microneedle body 41 can adopt the setting of a non-smooth surface, for example, at least one protrusion 42 is arranged in the circumferential direction of the middle part 412, the protrusion 42 extends radially along the microneedle 4, and has a tip away from the microneedle body 41, Alternatively, the circumferential direction of the needle tip 411 protrudes from the needle hub 413 ....

Embodiment 2

[0085] The difference between this embodiment and Embodiment 1 is that the microneedle main body 41 is a cone shaped as an elliptical fan in horizontal projection: the protrusion 42 is located on the edge of the microneedle main body 41 connecting the tip of the elliptical fan-shaped bottom surface, and is located at the level of the microneedle main body 41 The minor axis side of the projection.

[0086] Compared with Example 1, the microneedle 4 of this example increases the drug loading capacity of the microneedle 4 to meet the dosage form requirements of different medicines. In addition, because human skin is an anisotropic material, such as human torso skin, there is a significant difference in transverse and longitudinal elasticity. The transverse elasticity is weak and the stress is large, while the longitudinal elasticity is strong and the stress is small. The difference between the longitudinal and transverse stress values ​​is nearly doubled. The greater stress of th...

Embodiment 3

[0088] refer to Figure 5-6 As shown, the difference between this embodiment and Embodiment 1 is that the microneedle body 41 is a triangular pyramid: the protrusion 42 is located on the edge of the microneedle body 41 to reduce the resistance when the microneedle 4 penetrates the skin. When a protrusion 42 is provided, the protrusion 42 is located on the edge perpendicular to the base layer, so as to further reduce the resistance when the microneedle 4 penetrates the skin.

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Abstract

The invention relates to a microneedle patch which comprises a substrate layer and at least one microneedle arranged on the substrate layer, each microneedle comprises a microneedle body and at least one protrusion arranged on the microneedle body, and the protrusions extend from the needle tip to the substrate layer in the radial direction of the microneedles and are provided with tip ends far away from the microneedle bodies. The micro-needle has the advantages that the protrusions are arranged on the micro-needle and extend from the needle point to the base layer in the radial direction of the micro-needle, after the micro-needle punctures and enters the skin, the micro-needle is anchored in the skin through the protrusions, the grasping force of the micro-needle and the skin is increased, the micro-needle is prevented from being disengaged from the skin due to pushing of elastic deformation of the skin, continuous and accurate drug delivery is achieved, and the drug delivery efficiency is improved. And the administration effect is ensured. When the micro-needle patch is used, after the micro-needle is punctured into the skin, the protrusions on the micro-needle are embedded into the skin, the adhesive force between the micro-needle and the skin is enhanced, and therefore the base layer can be torn off immediately after the micro-needle is punctured into the skin, and the comfort level and attractiveness of the micro-needle patch are improved when the micro-needle patch is used.

Description

technical field [0001] The invention relates to the field of microneedle technology, in particular to a microneedle patch. Background technique [0002] For nearly a hundred years, metal injection needles have been widely used in the medical industry as a mainstream device for drug injection, but some people (especially children) find it difficult to accept the pain and fear caused by the use of metal injection needles. With the advancement and development of science and technology, microneedle patches for drug injection have come out. [0003] Microneedle patches generally include a base layer and microneedles arranged sequentially from top to bottom, and the microneedles are soluble. When in use, press the side of the microneedle patch where the microneedles are set on the skin until the microneedles penetrate into the skin and the base layer is attached to the skin. Due to the short length of the microneedle, the process of microneedle puncture into the skin will not ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0046
Inventor 马永浩李成国冷钢陈锦永陈莲华李燕芬王鉴哲
Owner YOUWE ZHUHAI BIOTECH CO LTD
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