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Preparation method of artificial skin

A technology of artificial skin and synthetic materials, applied in metal processing equipment, manufacturing tools, additive manufacturing, etc., can solve the problem that the look and feel is not specific enough, the whitening and tactile sensation cannot be fully displayed, the texture structure and tactile sensation are similar to the mechanical properties and biological phase of human skin. problems such as lack of compatibility, to achieve the effect of improving mechanical properties and biocompatibility

Pending Publication Date: 2022-05-20
EAST CHINA UNIV OF SCI & TECH
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  • Claims
  • Application Information

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Problems solved by technology

The current artificial skin can mainly show some tactile sensations similar to human skin, and can be used in pharmacokinetic experiments or toxicity experiments. However, such skin structures are not specific enough in terms of perception and texture. Human skin-like mechanical properties and biocompatibility are lacking, making it impossible to fully demonstrate in the display of various products, including whitening and touch.

Method used

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  • Preparation method of artificial skin
  • Preparation method of artificial skin
  • Preparation method of artificial skin

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Embodiment Construction

[0019] Hereinafter, the technology of the present application will be described in detail in combination with specific implementation manners. It should be understood that the following specific embodiments are only used to help those skilled in the art understand the present application, rather than limiting the present application.

[0020] In this embodiment, a method for preparing artificial skin is provided, including step 1: preparing synthetic materials.

[0021] In step 1, the synthetic material comprises a hydrogel, a photoinitiator and a modified biodegradable polymer material; wherein, the volume ratio of the hydrogel to the photoinitiator is 7.5:1, and the The volume ratio of the photoinitiator to the modified biodegradable polymer material is 2:1˜1:20.

[0022] The hydrogel is a conventional commercially available hydrogel in the art, the photoinitiator is LAP, and the modified biodegradable polymer material is collagen modified by methacrylic acid or methacrylic...

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Abstract

The invention provides a preparation method of artificial skin. The preparation method comprises the following steps: preparing a synthetic material; and a step of three-dimensional printing, wherein in the step of preparing the synthetic material, the synthetic material comprises hydrogel and a photoinitiator, and the volume ratio of the hydrogel to the photoinitiator is 7.5: 1; in the three-dimensional printing step, the synthetic material is prepared into the artificial skin through a three-dimensional printing device, or a mold for preparing the artificial skin is prepared through the three-dimensional printing device; moreover, the surface of the artificial skin prepared by the preparation method is provided with a plurality of textures, and the distribution of the plurality of textures simulates the texture of the epidermis of a human body.

Description

technical field [0001] This application relates to the field of biomedical equipment, in particular to a method for preparing artificial skin. Background technique [0002] As the largest organ in the human body, skin tissue is the main barrier for the human body to isolate external substances. It has a complex multi-layer structure to protect organs and tissues, and to ensure that the human body is free from mechanical, chemical, physical and pathogenic microorganisms. Invasion plays an indispensable role in the maintenance of life. The skin is often in direct contact with various cosmetics in daily life, so a suitable skin model can perform skin function tests and more clearly and accurately show the efficacy of cosmetics to the public. The current artificial skin can mainly show some tactile sensations similar to human skin, and can be used in pharmacokinetic experiments or toxicity experiments. However, such skin structures are not specific enough in terms of perception...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/386B29C64/20B29C64/25B33Y30/00B33Y50/00
CPCB29C64/386B29C64/20B29C64/25B33Y50/00B33Y30/00
Inventor 张洪波杨天豪马磊殷瑞雪李洪林邢天龙孙雯暄
Owner EAST CHINA UNIV OF SCI & TECH
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