The invention discloses a manufacturing method of high count and high density down-proof cloth. The cloth of the invention is made from a long-staple cotton combed yarn after procedures of warping, sizing, reeding, air-jet weaving, cloth inspecting, finishing, packing and stocking, etc. The sized yarn is made from mixed slurry of PVA and etherifying starch and sized by double-clip-double-nip and high temperature sizing; the weaving adopts the air-jet weaving and the ratio of a weft tension peak value and weft tension strength is controlled to be less than or equal to 55 percent. The invention is characterized by simple operation, easy control, high production efficiency and product quality, high cloth quality of produced products, smooth, even and clean cloth surface, soft and fine texture, erect and smooth hand feeling, special high moisture absorption and discharging performance, and the invention resembles to imitating the style of silk fabric, which is beneficial for improving downstream processing procedure and processing quality.