Monatomic platinum composite cerium dioxide nanoparticle for tumor electrodynamic therapy and preparation method of monatomic platinum composite cerium dioxide nanoparticle

Abstract

The invention provides monatomic platinum composite cerium dioxide nanoparticles for tumor electrodynamic therapy and preparation thereof, the composite nanoparticles are specifically formed by loading platinum monatomic on the surface of cerium dioxide, and the composite nanoparticles can be rod-shaped, spherical, sheet-shaped and the like. Under the action of an electric field of which the external strength and position can be accurately controlled, the composite nanoparticles can generate reactive oxygen species (ROS) with a tumor killing effect in a tumor, so that a tumor treatment effect is achieved. And cerium dioxide has peroxidase-like properties, so that the composite nanoparticles can catalyze hydrogen peroxide overexpressed in tumor cells to generate hydroxyl radicals, and the effect of chemodynamic therapy is achieved. Therefore, the composite nanoparticles can be used for chemical power and electric power combined therapy, and the defect that the activity of conventional chemical power therapy is poor is overcome. Moreover, due to the controllability of an external electric field, the selective treatment capability and spatial precision of the material can be effectively improved, and targeted treatment of tumors is realized.

Description

Single-atom platinum composite ceria nanoparticles for tumor electrodynamic therapy and the same preparation technical field The invention belongs to the technical field of inorganic nano-enzymes, be specifically related to a kind of single-atom platinum for tumor electrodynamic therapy Composite ceria nanoparticles and their preparation. Background technique In recent years, chemodynamic therapy (CDT) is one of the research hotspots in the field of cancer treatment. Novel tumor therapy technology based on the transformation reaction of endogenous chemical products in tumors. Unlike traditional tumor treatment techniques, chemokinetics Mechanotherapy uses the tumor microenvironment to activate the Fenton reaction (Fenton-like reaction) to generate strong oxidative hydroxyl radicals. For tumor-specific therapy, it utilizes the Fenton / Fenton-like reaction to induce apoptosis and necrosis. In the Fenton reaction, the transition Metal ions catalyze hydrogen peroxid...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantage of poor activity of conventional chemokinetic therapy, and to provide a single-atom platinum composite ceria nanoparticle for electrokinetic therapy of tumors and its preparation. The nanoparticle can be precisely controlled in strength and position Under the action of an electric field, reactive oxygen species (ROS) with tumor-killing effects can be generated inside the tumor, thereby achieving the effect of treating tumors

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