Low-temperature mechanical perfusion preservation device and method

Abstract

The invention provides a low-temperature mechanical perfusion preservation device and method, and the device comprises an organ box for placing an organ to be transplanted, a coolant container, a filter, a bubble catcher, a semiconductor refrigeration element, a pump, a perfusion loop, a circulation loop, a sensor assembly, an electromagnetic valve assembly, and a control display unit. Wherein the sensor assembly comprises a bubble sensor, a pressure sensor, a flow sensor and a temperature sensor, the coolant container is arranged on the periphery of the organ box in a surrounding mode, an open hole is formed in the side edge of the coolant container, and the temperature sensor detects the temperature of perfusate in the organ box through the open hole; the bubble catcher comprises three openings which are respectively a liquid inlet, a filling outlet and a circulating outlet, a partition plate is vertically arranged at the bottom of the bubble catcher, and the partition plate divides the bubble catcher into a plurality of communicated cavities; and the semiconductor refrigeration element is assembled outside the bubble catcher. The low-temperature mechanical perfusion storage device can directly detect the temperature of perfusate, the perfusate with the temperature exceeding the standard can be cooled to the set temperature range as soon as possible, bubbles can be prevented from entering a perfusion pipeline as far as possible, and the accuracy of perfusion data and perfusion safety are improved.

Description

technical field

[0001] The invention belongs to the field of biomedical instruments, and in particular relates to a low-temperature mechanical perfusion preservation device and method for organ transplantation. Background technique

[0002] Organ transplantation is the surgical transfer of viable isolated organs into a patient. During organ storage, the temperature must be controlled at a low temperature of 2-8 °C. The traditional method of organ preservation is static cold storage. The longer the static cryopreservation time, the higher the incidence of delayed functional recovery of the graft after surgery. In addition, the static cryopreservation method is difficult to objectively evaluate isolated organs. Compared with static cryopreservation, low-temperature mechanical perfusion of isolated organs can significantly reduce the incidence of delayed recovery of graft function, which is beneficial to improve the long-term survival rate of transplanted organs. At the same t...

Examples

Embodiment Construction

[0043]The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. However, the embodiments described below are only a part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0044] Figure 1-3 An embodiment of the cryogenic mechanical perfusion preservation device is shown, which mainly includes an organ box (not shown) for placing the organ to be transplanted, an ice box 1, a pump 2, a filter 10, a bubble trap 11, a semiconductor refrigeration element 9. Perfusion circuit, circulation circuit, sensor assembly, solenoid valve assembly 3, 4, 5, control and display unit 6, wherein the sensor assembly includes a bubble se...

technical field

[0001] The invention belongs to the field of biomedical instruments, and in particular relates to a low-temperature mechanical perfusion preservation device and method for organ transplantation. Background technique

[0002] Organ transplantation is the surgical transfer of viable isolated organs into a patient. During organ storage, the temperature must be controlled at a low temperature of 2-8 °C. The traditional method of organ preservation is static cold storage. The longer the static cryopreservation time, the higher the incidence of delayed functional recovery of the graft after surgery. In addition, the static cryopreservation method is difficult to objectively evaluate isolated organs. Compared with static cryopreservation, low-temperature mechanical perfusion of isolated organs can significantly reduce the incidence of delayed recovery of graft function, which is beneficial to improve the long-term survival rate of transplanted organs. At the same t...

Examples

Embodiment Construction

[0043]The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention. However, the embodiments described below are only a part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0044] Figure 1-3 An embodiment of the cryogenic mechanical perfusion preservation device is shown, which mainly includes an organ box (not shown) for placing the organ to be transplanted, an ice box 1, a pump 2, a filter 10, a bubble trap 11, a semiconductor refrigeration element 9. Perfusion circuit, circulation circuit, sensor assembly, solenoid valve assembly 3, 4, 5, control and display unit 6, wherein the sensor assembly includes a bubble se...

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