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Nepetalactone as well as preparation method and application thereof

A technology of Schizonepeta schizonepeta and Schizonepeta, applied in the field of nepetalactone and its preparation, which can solve the problems of less research on chemical components

Pending Publication Date: 2022-08-05
新疆维吾尔自治区中药民族药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although modern pharmacological studies have shown that its extracts have significant anticancer activity, there are few related studies on the characterization of its chemical constituents

Method used

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  • Nepetalactone as well as preparation method and application thereof
  • Nepetalactone as well as preparation method and application thereof
  • Nepetalactone as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: This Vanguerolactone, the chemical structural formula is:

[0031]

Embodiment 2

[0032] Embodiment 2: as the optimization of above-mentioned embodiment, obtain according to the following method: a kind of preparation method of Vanguerolactone, it is characterized in that carrying out according to the following steps: the first step, the aboveground part of Nepeta bud is pulverized and sieved, with distilled water Decoct and extract for 2 times, 1 to 3 hours each time, combine each decoction liquid, recover under reduced pressure, and concentrate to obtain a decoction of the aerial part of Nepeta japonicus; in the second step, decoct the aerial part of Nepeta japonicus in water The liquid was passed through D101 macroporous adsorption resin, eluted with ethanol-water gradient, and the 30% ethanol eluted part was concentrated into extract; in the third step, the extract was taken from the 30% ethanol eluted part and passed through AB-8 macroporous resin, with Ethanol-water gradient elution, taking the 10% ethanol elution part and concentrating it into extract...

Embodiment 5

[0033] Embodiment 5: The preparation method of this Vanguerolactone is carried out according to the following method: In the first step, the aerial part of Nepeta japonicus is pulverized and sieved, decocted and extracted twice with distilled water for 1 to 3 hours each time, and combined each decoction The boiled liquid is recovered under reduced pressure and concentrated to obtain a decoction of the aerial part of Nepeta japonicus; in the second step, the above-ground part of the decoction of Nepeta japonicus is passed through D101 macroporous adsorption resin, eluted with an ethanol-water gradient, and the mixture is obtained. The 30% ethanol eluted part is concentrated into extract; the third step, the extract of 30% ethanol eluted part is taken through AB-8 macroporous resin, eluted with ethanol-water gradient, and the 10% ethanol eluted part is concentrated into extract; In the fourth step, take the 10% ethanol elution part of the extract and carry out ODS reversed-phase ...

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Abstract

The invention relates to the technical field of separation and purification of overground parts of schizonepeta bracteata, in particular to schizonepeta bracteata lactone as well as a preparation method and application thereof. The invention discloses the Vangurolactone for the first time, and the Vangurolactone disclosed by the invention has a relatively strong in-vitro inhibition effect on the drug-resistant glioma, so that the Vangurolactone can be applied to preparation of the drug for preventing the glioma.

Description

technical field [0001] The invention relates to the technical field of separation and purification of aerial parts of Nepeta bracteria, and relates to a nepetalactone, a preparation method and application thereof, wherein the nepetalactone is the abbreviation of Vanguerolactone. Background technique [0002] Nepeta bracteata Benth. Nepeta bracteata Benth. is a Nepeta plant of the Labiatae family. The Uyghur name is also "Zufa", and the dried whole plant is used as medicine. Studies have shown that the whole plant contains flavonoids, triterpenes, alkanes, steroids and volatile oils. It has the functions of relieving cough and relieving asthma, clearing heat and removing dampness. It is used to treat trachea inflammation, such as cough and asthma, cold and fever, and dysuria. Although modern pharmacological studies have shown that its extract has significant anticancer activity, there are few relevant studies to characterize its chemical constituents. The ursolic acid-type ...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61P35/00A61K31/585A23L33/105
CPCC07J71/0005A61P35/00A23L33/105A23V2002/00A23V2200/308
Inventor 石磊岭马国需魏鸿雁樊从照孙照翠刘红玉宋海龙
Owner 新疆维吾尔自治区中药民族药研究所
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