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Pharmaceutical compositions containing aminothiazole derivatives for treatment of colonic motion dysfunctions

A technology of motility dysfunction, aminothiazole, applied in colon motility dysfunction drugs, a therapeutic field of colon motility dysfunction, which can solve problems such as lower gastrointestinal diseases that are not mentioned

Inactive Publication Date: 2006-07-19
ZERIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these publications do not mention ameliorating effects on lower gastrointestinal diseases caused by colonic motility dysfunction

Method used

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  • Pharmaceutical compositions containing aminothiazole derivatives for treatment of colonic motion dysfunctions
  • Pharmaceutical compositions containing aminothiazole derivatives for treatment of colonic motion dysfunctions
  • Pharmaceutical compositions containing aminothiazole derivatives for treatment of colonic motion dysfunctions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] The present invention will be described in detail later with examples. However, it should be noted that the present invention is not limited to these embodiments only.

[0028] 【Pharmacology Test】

[0029] The pharmacological test of the specific aminothiazole derivative (I) of the present invention is described below. The following are the drugs (test compounds) used in the test.

[0030] (Compound 1)

Embodiment 38

[0031] N-(N',N'-Diisopropylaminoethyl)-[2-(2-hydroxy-4,5-dimethoxybenzoylamino)-1,3-thiazol-4-yl] Formamide trihydrate [Synthesized according to the method of Example 38 of WO96 / 36619]

[0032] (Compound 2)

Embodiment 1

[0033] N-(N',N'-Diisopropylaminoethyl)-[2-(3-cyano-benzoylamino)-1,3-thiazol-4-yl]carboxamide hydrochloride [according to Synthesis by the method of Example 1 of WO98 / 17654]

[0034] (Compound 3)

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PUM

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Abstract

Remedies effective for the improvement of colonic motor dysfunction such as irritable bowel syndrome, constipation or intestinal atony without causing side effects on the central nerve system. These colonic motor dysfunction remedies comprise, as active ingredients, aminothiazole derivatives represented by the following formula (I) or a salt or hydrate thereof: wherein R<1>, R<2> and R<3> may be the same or different and each independently represent a hydrogen atom or a hydroxyl, lower alkyl, lower alkoxy, amino, nitro or cyano group, R<4> and R<5> may be the same or different and each independently represent a hydrogen atom or a lower alkyl group, and n stands for an integer of from 2 to 4.

Description

Technical field [0001] The present invention relates to drugs for colonic dyskinesia, and more specifically refers to colonic dyskinesia drugs containing aminothiazole derivatives as active ingredients. The invention also relates to a treatment method for colonic motor dysfunction. technical background [0002] From an anatomical point of view, the digestive tract can be roughly divided into upper digestive tract and lower digestive tract. The upper digestive tract includes the esophagus, stomach, and duodenum, while the lower digestive tract includes the small intestine, large intestine, and rectum. For the diseases and symptoms of various parts, the corresponding treatment is adopted. [0003] Illustrative upper gastrointestinal diseases are diseases of the esophagus, such as esophageal cancer, esophageal stenosis, and reflux esophagitis; stomach diseases, such as gastric ulcer, gastritis, and gastric cancer; diseases of the duodenum, such as duodenal ulcer and Duodenal cancer;...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/426A61P1/00A61K31/381A61P1/10
CPCA61K31/426A61K31/381A61P1/00A61P1/10
Inventor 上木茂堀裕子松永勇吾长泽正明西冈裕康村田正和
Owner ZERIA PHARMA