Unlock instant, AI-driven research and patent intelligence for your innovation.

Pharmaceutical compositions containing aminothiazole derivatives for treatment of colonic motion dysfunctions

A technology for motility dysfunction, colon, applied in the field of colon motility dysfunction drugs, a therapeutic field of colon motility dysfunction, which can solve problems such as lower gastrointestinal diseases that are not mentioned

Inactive Publication Date: 2003-12-03
ZERIA PHARMA
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these publications do not mention ameliorating effects on lower gastrointestinal diseases caused by colonic motility dysfunction

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical compositions containing aminothiazole derivatives for treatment of colonic motion dysfunctions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 38

[0028] N-(N',N'-diisopropylaminoethyl)-[2-(2-hydroxy-4,5-dimethoxybenzoylamino)-1,3-thiazol-4-yl] Formamide trihydrate [synthesized according to the method of Example 38 of WO96 / 36619]

[0029] (compound 2)

Embodiment 1

[0030] N-(N', N'-diisopropylaminoethyl)-[2-(3-cyano-benzoylamino)-1,3-thiazol-4-yl]formamide hydrochloride [according to Example 1 method synthesis of WO98 / 17654]

[0031] (composition 3)

Embodiment 157

[0032] N-(N', N'-diisopropylaminoethyl)-[2-(3-aminobenzoylamino)-1,3-thiazol-4-yl]formamide [according to the implementation of WO96 / 36619 Example 157 method synthesis]

[0033] Trial 1 [Effect on stomach and colon motility]

[0034] A load cell ("F-12IS", trade name; manufactured by Starmedical Technologies, Inc.) was permanently sutured to the stomach of male dogs (body weight: 9 to 11 kg, 5 to 6 dogs per group) Sinus and large intestine (Itoh Z. et al., Am. J. Dig. Dis. 22, 117-124, 1977). The contraction signal of the corresponding area after eating was amplified and recorded ("RTA-1200", trade name; manufactured by Nihon Kohden Co.). The contraction signal collected in the computer was analyzed with software ("DSSDDWHD V.30", trade name; provided by Nihon Kohden Co.), and a motor index was calculated. The test drugs were administered separately using catheters that had been chronically implanted in the duodenum. Assuming that the motor index 30 minutes before the admi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Remedies effective for the improvement of colonic motor dysfunction such as irritable bowel syndrome, constipation or intestinal atony without causing side effects on the central nerve system. These colonic motor dysfunction remedies comprise, as active ingredients, aminothiazole derivatives represented by the following formula (I) or a salt or hydrate thereof: wherein R<1>, R<2> and R<3> may be the same or different and each independently represent a hydrogen atom or a hydroxyl, lower alkyl, lower alkoxy, amino, nitro or cyano group, R<4> and R<5> may be the same or different and each independently represent a hydrogen atom or a lower alkyl group, and n stands for an integer of from 2 to 4.

Description

technical field [0001] The present invention relates to a drug for colon motility dysfunction, more specifically a drug for colon motility dysfunction containing aminothiazole derivatives as active ingredients. The invention also relates to a method of treatment for colon motility dysfunction. technical background [0002] From an anatomical point of view, the digestive tract can be roughly divided into upper and lower digestive tracts. The upper GI tract includes the esophagus, stomach, and duodenum, while the lower gastrointestinal tract includes the small intestine, large intestine, and rectum. For the diseases and symptoms of each part, corresponding treatment is adopted. [0003] Illustrative upper gastrointestinal diseases are diseases of the esophagus, such as esophageal cancer, esophageal stricture, and reflux esophagitis; diseases of the stomach, such as gastric ulcer, gastritis, and gastric cancer; diseases of the duodenum, such as duodenal ulcer and Duodenal ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/381A61K31/426A61P1/00A61P1/10
CPCA61K31/381A61K31/426A61P1/00A61P1/10
Inventor 上木茂堀裕子松永勇吾长泽正明西冈裕康村田正和
Owner ZERIA PHARMA