13 results about "Atony" patented technology

The present disclosure relates treating skeletal muscle weakness associated with heart failure by administering a compound that binds to leaky ryanodine receptors (RyRs). Compounds of the present disclosure can bind to and repair the leak in both RyR1 and RyR2 to improve skeletal muscle and cardiac function, respectively.

The present invention relates to a method for obtaining a functionally enhanced mitochondria and a use thereof, and specifically, to: a mitochondria isolated from cells overexpressing glutathione synthase; and a use thereof for preventing, alleviating, or treating muscle weakness-related diseases.

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and / or pulmonary hypertension.

Disclosed are methods of improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, reducing muscle atrophy, reducing muscle weakness, increasing muscle mass, and / or increasing muscle strength in a patient being treated with a GLP-1 receptor agonist, by administering to the patient a compound of formula (I) or a pharmaceutically acceptable salt thereof. Combinations of a GLP-1 receptor agonist and a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, reducing muscle atrophy, reducing muscle weakness, increasing muscle mass, and / or increasing muscle strength in a patient are also provided.

The invention discloses a traditional Chinese medicine composition for treating Bell paralysis sequelae. The traditional Chinese medicine composition is prepared from the following raw material medicines: astragalus membranaceus, angelica sinensis, radix rehmanniae preparata, ligusticum wallichii, parched white peony root, kudzu vine root, cortex albiziae, pawpaw, semen coicis, lycopodium clavatum, caulis spatholobi and angelica dahurica. The invention further discloses a traditional Chinese medicine compound preparation for treating the Bell paralysis sequelae and application of the traditional Chinese medicine composition or the traditional Chinese medicine compound preparation to preparation of medicine for treating the Bell paralysis sequelae. The traditional Chinese medicine composition has a remarkable curative effect on Bell facial paralysis sequelae such as mouth-eye linkage, facial spasm and facial muscle tension and weakness, can remarkably relieve facial tension, relieve mouth-eye linkage, relieve facial spasm and improve the living quality and mental state of a patient, is remarkable in treatment effect, can adjust and add or reduce the formula according to specific diseases, and is free of toxic and side effects. The method has great popularization and application values.

Disclosed are methods of improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, increasing muscle mass, and / or increasing muscle strength in a subject being treated with a GLP-1 receptor agonist, by administering to the subject a compound of formula (I) or a pharmaceutically acceptable salt thereof. Combinations of a GLP-1 receptor agonist and a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, reducing muscle atrophy, reducing muscle weakness, increasing muscle mass, and / or increasing muscle strength in a subject are also provided.

The invention features polypeptides that include an extracellular ActRIIa variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIa variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, e.g., Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, sarcopenia; or cancer cachexia; or metabolic diseases, e.g., obesity, Type-1 diabetes, or Type-2 diabetes.

Disclosed herein are products, methods, and uses for treating, ameliorating, delaying the progression of, and / or preventing a disease or disorder associated with expression of an aberrant lamin A (LMNA) gene or progerin gene. Such disease or disorder includes, but is not limited to, a laminopathy, progeroid syndrome, progeria, or aging disorder resulting from the aberrant expression of LMNA or progerin. In some instances, the progeria is Hutchinson-Gilford progeria syndrome (HGPS). In some instances, the disease or disorder associated with the expression of progerin is premature aging or natural aging including, but not limited to, atherosclerosis, alopecia, osteoporosis, cardiovascular disease, skin abnormalities, fat storage, stroke, myocardial infarction, stroke, heart failure, muscle wasting, muscle weakness, myotonia, skeletal muscle problems, abnormalities of the retina, hip weakness, abdominal muscle weakness, joint and spinal abnormalities, lower leg weakness, shoulder weakness, hearing loss, and / or tissue inflammation. More particularly, disclosed herein are RNA interference-based products, methods, and uses for inhibiting or downregulating the expression of progerin. Even more particularly, the disclosure provides guide RNA and a CRISPR endonuclease for inhibiting or downregulating the expression of progerin and methods of using said guide RNA and a CRISPR endonuclease to correct a mutation in the LMNA gene and inhibit or downregulate progerin expression in cells and / or in cells of a subject having a condition resulting from the expression of progerin including, but not limited to, HGPS or progeria, an HGPS-like condition affecting LMNA mutations that affect exon 11 splicing, or a condition resulting from the expression of progerin.

The present invention relates to a composition for preventing, improving, or treating diseases associated with muscle weakness, comprising a celery seed extract. The celery seed extract according to the present invention is a natural product and can increase muscle mass and strength with few or no side effects. Therefore, it is expected that the celery seed extract according to the present invention can be useful for preventing, improving, or treating diseases associated with muscle weakness, metabolic diseases, liver diseases, etc., since it can increase muscle mass and strength with few or no side effects by using a natural product and can not only prevent muscle weakness, but also inhibit increases in body weight and body fat, and reduce blood lipid concentrations and liver toxicity indicators (GOT and GPT).

The utility model discloses an exoskeleton support system for lower limb muscle asthenic, aims at solving the problem that the existing support device cannot adjust support force according to the rehabilitation stage demand. The system comprises a square frame, a moving mechanism, a vertical connecting plate, a sliding slot, a sliding block, a motor, a mounting plate and a support mechanism. The support mechanism is composed of a support column and a moving column, is provided with a telescopic rod and a tension spring, and can adjust the support degree. The binding belt and the adjusting belt can be adjusted individually according to the patient condition. The system reduces the dependence on the physiotherapist, improves the rehabilitation resource efficiency, is suitable for rehabilitation training and daily life assistance, has simple structure, low cost and economy.

Short expansion mutations in PABPN1 cause adult-onset, autosomal dominant oculopharyngeal muscular dystrophy (OPMD). The molecular hallmark of OPMD is the presence of insoluble nuclear aggregates of the expanded (exp)PABPN1. The aggregation of PABPN1 results in reduced levels of functional PABPN1. In OPMD, PABPN1 levels are under a critical threshold which leads to muscle weakness. Interestingly, reduced levels of PABPN1 are also found in ageing muscles, where these reduced levels lead to muscle atrophy and has also been found to be associated with other adult-onset pathologies affecting tissues other than skeletal muscles, such as cancers, including bladder cancer, and heart diseases.

The invention discloses a masticatory muscle recovery training appliance, and relates to the technical field of masticatory muscle training, the masticatory muscle recovery training appliance comprises a support frame, the outer surface of the support frame is provided with a masticatory training assembly for training masticatory muscles of a gout patient, the masticatory training assembly comprises a limiting frame, and the outer surface of the masticatory training assembly is provided with a saliva absorption assembly. According to the masticatory muscle recovery training tool, when a large amount of hydrops appears in the oral cavity in the process that a moderate wind patient uses the masticatory muscle training device, the two occlusal pads are moved forwards into the oral cavity of the patient and between upper and lower incisor teeth, so that the oral cavity of the patient is supported, and then the suction catheter is inserted into the oral cavity of the patient; waste liquid is absorbed through driving of the negative pressure pump, meanwhile, saliva in the oral cavity of the patient is comprehensively absorbed by rotating the suction catheter, and the problem that in the prior art, due to the fact that the stroke patient swallow too slowly and weakly, the patient feels uncomfortable and cannot concentrate on masticatory muscle power generation control, and training efficiency is reduced is solved.

The present application relates to a kind of traditional Chinese medicine composition for treating spleen deficiency syndrome heart failure with cognitive dysfunction, including the following weight parts of traditional Chinese medicine composition: 18-22 parts of Huangqi, 8-12 parts of Renshen, 13-17 parts of Baishu, 13-17 parts of Shanyao, 13-17 parts of Fuling, 8-12 parts of Zexie, 8-12 parts of Huangjing, 8-12 parts of Danggui, 8-12 parts of Chuanqiong, 8-12 parts of Maidong, 8-12 parts of Zhimu, 5-7 parts of Wuyi, 8-12 parts of Chenpi, 5-7 parts of Guizhi, 8-12 parts of Hongjingtian, 10-14 parts of Wujiapi and 5-7 parts of Zhigancao.The preparation method of the present application is mainly decoction and granulation.The present application is suitable for spleen deficiency syndrome, such as fatigue, chest tightness, dyspnea, edema, dizziness, palpitation, abdominal distension, poor appetite, or cold, weak or loose stool, difficult urination, dull expression, slow speech and action, and other symptoms.Specifically suitable for heart failure with cognitive dysfunction with the above symptoms.