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Anti-cold medicine soft capsule and its preparing method

A soft capsule and drug technology, applied in the field of medicine, can solve the problems of unfavorable drug components, balanced absorption, easy aggregation into clusters, etc., and achieves the effects of fast drug dissolution rate, high bioavailability, and good therapeutic effect.

Active Publication Date: 2007-04-18
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the drug is in the form of a tablet. After entering the human body, the solid drug is dissolved by water and digestive juice, and the active ingredients of the drug are slowly dissolved, resulting in a slow onset of action, and some of the hydrophobic components are easy to aggregate into groups after dissolution. , is not easily absorbed by the body, and the time required from taking it to exerting its effect is prolonged
In addition, in order to overcome the shortcomings of tablets, some existing soft capsule drugs use vegetable oil as a dispersant to dissolve the active ingredients of the drug. However, a single vegetable oil solvent has different solubility for different drugs, and its liquid phase often appears uneven, turbid, and separated. layer and other problems, which is not conducive to the balanced absorption of the various ingredients of the drug by the human body, and reduces the bioavailability of the active ingredient of the drug

Method used

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Effect test

Embodiment Construction

[0019] The anti-cold medicinal capsule provided by the invention includes active medicinal ingredients and fillers. The active ingredients of the medicine are paracetamol, pseudoephedrine hydrochloride and anhydrous dextromethorphan hydrobromide. Acetaminophen is an antipyretic and analgesic drug, which can reduce prostaglandin synthesis by inhibiting prostaglandin synthase to achieve antipyretic and analgesic effects; Antitussive effect; pseudoephedrine hydrochloride can shrink capillaries and reduce capillary permeability. The compound preparation composed of the three medicines can give full play to the complementary effects of the three components, and has a good therapeutic effect on various symptoms caused by colds. In order to enable the medicine to be absorbed by the human body more quickly and fully, the present invention also adds a filler composed of a dispersion medium, a microemulsifier, a suspending agent and a surface active agent. Among them, polyethylene gly...

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Abstract

The present invention provides a soft anti-cold medicine capsule and its preparation process and belongs to the field of medicine technology. The content consists of active medicine component and stuffing, the active medicine component includes acetaminophen, pseudoephedrine hydrochloride and dextromethorphan hydrobromide, and the stuffing includes dispersing medium, surfactant, suspension assistant and microemulsifier. The present invention has fast acting and obvious curative effect on cold syndrome, and the soft capsule is clear and transparent.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to an easily absorbed compound mixture anti-cold medicine and a preparation method thereof, which belong to the technical field of medicine. Background technique [0002] Cold is a common disease and frequently-occurring disease, especially in spring and winter, when the incidence rate is high. Its symptoms are nasal congestion, runny nose, headache, cough, fever, etc., which make people feel very uncomfortable and will affect normal life in severe cases. Currently, there are various anti-cold medicines on the market, most of which are compound preparations. The compound preparation mainly utilizes the synergistic effect between the various medicines, brings into play the advantages of each medicine, and achieves the purpose of symptomatic treatment. For example, paracetamol has antipyretic and analgesic effects; dextromethorphan hydrobromide is a central antitussive dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K31/137A61K31/167A61K9/48A61P31/00
Inventor 齐新英郭卫芹李勇张清江韩卫占智彩辉
Owner CSPC OUYI PHARM CO LTD
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