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Emulsion-type lubricant and its application in medical rubber product

A lubricant and emulsion type technology, which is applied to non-active ingredients in medical preparations, pharmaceutical formulations, emulsion delivery, etc., can solve the problems of inability to provide a lubricant system and unsatisfactory use effects, and achieve long-lasting lubrication, Long duration of lubrication and good fluidity

Inactive Publication Date: 2002-07-03
GUANGZHOU WANFANGJIAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, pure water-based lubricants or oil-based lubricants cannot provide a lubricant system that dissolves a specific drug or dissolves two drugs with different solubility properties
[0009] It can be seen that the pure silicone oil-based lubricant and the pure water-based lubricant have their own advantages and disadvantages, and the use effect is far from ideal. If the advantages of the two can be combined and synergized, and their respective shortcomings can be overcome, it will be possible. Contribute a class of better medical lubricants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]Mix 100-200 ml of water, 100-200 ml of dimethicone with a viscosity of ≥100mpa.s, 10-30 ml of polyoxyethylene fatty alcohol ether and 5-15 ml of low-degree polymerized ethylene glycol, at ≥20,000 Under the shear force of rev / min for 2 to 5 minutes, a milky white emulsion is formed, and the viscosity is obviously increased. After being placed at 70°C for 7 days, the viscosity drop ratio is less than or equal to 10%, and the water-oil separation rate is less than or equal to 15%. Appearance color changed to very pale yellow. The emulsion type lubricant prepared by adding 0.5ml to each natural latex condom is taken, and the whole condom is basically lubricated within 7 days after the encapsulation film.

Embodiment 2

[0023] 1,000-3,000 ml of water-based lubricant (viscosity>100mpa.s) made of polyethylene glycol 1,000, and 1,300-4,500 ml of silicone oil with viscosity ≥80mpa.s and 100-300 ml of polyoxyethylene polyoxypropylene The copolymer and glycerin are mixed and acted in a vacuum emulsifier or under a high-speed shear force of ≥20,000 rpm for 5-15 minutes to form a milky white emulsion with a viscosity increase of 50%. After being placed at 70°C for 7 days, the water-oil separation rate is less than or equal to 10%, the appearance color becomes very pale yellow, and the viscosity is basically unchanged. Add 0.5ml of emulsion type lubricant made to each natural latex condom, 70% of the length of the condom is lubricated within 7 days after the encapsulation film.

Embodiment 3

[0025] In 100-300 ml of soluble polysaccharide water-based lubricant (viscosity ≥ 75mpa.s), add 280-330ml of dimethicone with a viscosity of 50mpa.s and 5-30 ml of polyoxyethylene sorbic acid. Acting in the ultrasonic field for more than 10 minutes or under the shear force of ≥15,000 rpm for 3 to 5 minutes, it is made into a milky white emulsion type lubricant. After being placed at 70°C for 7 days, the viscosity reduction ratio is less than 5%, the water-oil separation rate is less than 15%, and the appearance color becomes very pale yellow; all properties have no obvious change after being placed at room temperature for one month. The emulsion type lubricant prepared by adding 0.5ml to each natural latex condom is taken, and the whole condom is basically lubricated within 7 days after the encapsulation film. Take 0.3ml of the emulsion type lubricant made by adding it to the urethral catheter and insert it directly into the rabbit urine vagina. The ease of insertion is obviou...

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PUM

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Abstract

An emulsion-type lubricant and its application in medical rubber products are disclosed. The said lubricant including oil-in-water O / W-type one, water-in-oil W / O-type one and composite one is prepared from oily liquid matrix of organosilicon and water-base lubricant. The said water-base lubricant contains one or more of water, ethanediol, propanediol, glycerine, etc. The said oil-base contains oily liquid of organosilicon. Its advantage is high lubricating performance.

Description

technical field [0001] The present invention relates to chemical lubricants, especially a kind of emulsion type lubricant made of water base lubricant (or called water-soluble lubricant) and oil base lubricant, the present invention also relates to this type of emulsion type lubricant in some Application on medical devices (such as latex or silicone medical products, etc.). Background technique [0002] There are two types of human body medical lubricants widely used at present. One is lubricants based on oily medium, such as petrolatum and its derivatives, mineral oil (such as baby oil), etc.; the other is water-based lubricants made of water-soluble materials, such as KY lubricants, etc. . These lubricants are mainly used for lubrication during the treatment, nursing, or normal physiological functions of certain organs or tissues of the human body. [0003] During the production or use of medical devices (such as condoms, medical catheters, etc.) made of latex, silicone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/00A61P15/00A61P31/00A61P43/00
Inventor 卢智俊
Owner GUANGZHOU WANFANGJIAN MEDICINE
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