Method for extracting hypericin from Hypericum perforatum and medicine made up using hypericin as main composition

A technology of hypericin and an extraction method, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve the problems of allergy, low content of hypericin, complicated equipment, etc.

Inactive Publication Date: 2002-12-18
牛勃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In some patents (on March 15th, 2000, publication number CN 1247071A), its method is simple and easy, and the content of extracting hypericin is not high; in some patents (on July 18th, 2001, publication No. CN 1304397A), the extracted content is higher,...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The preparation of hypericin:

[0011] (1) According to the above-mentioned method, take 1000g of Hypericum perforatum, add KOH with a concentration of 1% and NaHCO with 8% 3 solution in 1000ml, soak and boil for 8 minutes, filter through gauze, and obtain the filtrate (a);

[0012] (2) The resulting residue was treated with 1.5% NaHCO 3 Solution 500ml, boiled for 8 minutes and filtered to obtain filtrate (b);

[0013] (3) combining the filtrates (a), (b) and drying to obtain the extract;

[0014] (4) The extract is dissolved in 500ml of propanol, the two are mixed and concentrated and filtered;

[0015] (5) Add high-concentration ethanol to the filtrate to make the alcohol content reach 65%, refrigerate, filter to obtain the alcohol liquid, reclaim the ethanol, then concentrate, refrigerate, and filter to obtain the filtrate; adjust the ethanol concentration to 80% in the filtrate, and then refrigerate 1. After filtering to obtain the filtrate, reclaim the ethanol ...

Embodiment 2

[0025] Tablets containing the extract of Example 1:

[0026] (1) 150 g of the extract obtained from Hypericum perforatum in Example 1 was pulverized.

[0027] (2) According to the national standard, the pulverized product is mixed with 50 g of taurine, 2 g of zinc, 10 g of vitamin C, 2.5 g of vitamin E, sweetener and other ingredients.

[0028] (3) Adding a pharmaceutically acceptable carrier such as a wetting agent to the mixture to make it into a soft material, and then drying it under vacuum.

[0029] (4) Make the dried material into granules with appropriate thickness and elasticity and dry.

[0030] (5) After adding a wetting agent to the granules, mix them evenly, and press them into tablets with a special tablet press machine, each tablet weighing 250 mg.

Embodiment 3

[0032] Pharmacodynamic research:

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PUM

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Abstract

The method for extracting hypericin from hypericum perforatum includes the following steps: soaking plant hypericum perforatun in KOH and NaHCO3 solution with a specific concentration, boiling, filtering and drying to obtain its extract, dissolving said extract in propyl alcohol, filtering solute, and using water-alcohol process to refine the extract so as to obtain the invented product. It is used as main component, and matched with other component, and can be made into the hypericin medicine composite or other different dosage forms for curing depression.

Description

Technical field: [0001] The invention relates to a method for extracting hypericin from Hypericum perforatum and a series of medicines for treating depression prepared by using hypericin as a main component. Background technique: [0002] Depression is an emotional disorder. With the accelerated pace of modern life, modern people are more likely to suffer from depression. It is manifested as extremely low mood, melancholy, and even the risk of suicide, which seriously affects the physical and mental health of patients. Relationships with family and friends are not functioning properly. Therefore, the treatment of depression has attracted the attention of various countries and the whole society. [0003] Hypericum perforatum (Hypericum perforatum L) is a plant of the genus Hypericum in the family Garcinia, and the extract of Hypericum perforatum—hypericin (hypericin) is the most biologically active substance in Hypericum perforatum, with antidepressant, antiviral and photody...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P25/24C07C50/36
Inventor 牛勃胥显民向前杨琦阎占清杨利军张悦红陈显久郭勇
Owner 牛勃
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