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Application of tribulus spirosteroid saponin compound in preparation of antifungal medicine

A technology of terrestris spiro steroid saponins and antifungal drugs, applied in the field of medicine, can solve the problems of no pharmacological experiment report, no antifungal activity of 14 compounds, etc.

Inactive Publication Date: 2003-07-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is reported that TTS-8, TT-16 and TTS-17 have antifungal activity (Bedir, A. Khan, et al. Biologically Active Steroidal Glycosides from Triblus terrestris. Pharmazie 2002; 57(7): 491-493), However, there is no systematic pharmacological experiment report, and there is no report that the other 14 compounds have antifungal activity.

Method used

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  • Application of tribulus spirosteroid saponin compound in preparation of antifungal medicine

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Embodiment Construction

[0006] The assay method of compound antifungal activity of the present invention is as follows:

[0007] (1). Bacterial solution preparation:

[0008] Pick a small amount of Candida albicans, Cryptococcus neoformans, Candida tropicalis and Candida parapsilosis from the SDA medium stored at 4°C with an inoculation ring, inoculate into 1ml of YEPD culture medium, culture at 35°C, shake at 250rpm, and activate for 16 hours , causing the fungus to be in a late exponential growth phase. Take the bacterial solution into 1ml YEPD culture solution, reactivate it with the above method, count it with a hemocytometer after 16 hours, and adjust the concentration of the bacteria solution to 1×10 with RPMI 1640 culture solution. 3 ~5×10 3 pieces / ml.

[0009] (2). Liquid preparation:

[0010] The test drugs were made into 6.4mg / ml solutions with DMSO, and stored at -20°C. Before the experiment, the 6.4mg / ml drug stock solution was taken out and melted in a 35°C incubator, and 10 μl of ea...

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Abstract

The present invention relates to the field of medicine technology, and provides an application of tribuli spironosaponin compound in preparation of antimycotic medicine. The crude extract of the Chinese medicine tribulus fruit can be mainly used for curing cardiovascular diseases, it has 17 kinds of tribuli spironosaponin components, and provides their chemical structure general formula. The tests show that said compounds have antimycotic activity, so that they can be used for preparing antimycotic medicine, also can be used for preparing fresh-keeping agent of food and fruit or sanitary articles.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to the application of tribulus terrestris saponins in the preparation of antifungal drugs. Background technique: [0002] The crude saponins (containing about 40% of total saponins) extracted from the traditional Chinese medicine Tribulus terrestris (Tribulus terrestris L.) are mainly used clinically to treat cardiovascular and cerebrovascular diseases, such as Xinnaoshutong Capsules and Xinnaoshutong Tablets. The total saponins extracted from Tribulus terrestris mainly include spirostanoid saponins and furostanol saponins, and 17 spirostanoid saponins have been reported [Xu YX, Chen HS, LiangHQ, et al.Three new saponins from Tribulus terrestris.Planta Med .2000; 66(6): 545~50; YanW, Ohtani K, Kasai R, et al. Steroidal Saponins from fruits of Triblus terrestris. Phytochemistry1996; 42(5): 1417~22; Yan W, Ohtani K, Kasai R , et al.Steroidal Saponins from fruits of Triblusterrestris....

Claims

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Application Information

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IPC IPC(8): A23L3/34A23L33/125A61P31/10C07J71/00
Inventor 陈海生徐一新姜远英温海曹永兵刘文庸张军东
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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