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Cyclovirobuxine D salt and its preparation and use, and process for preparing said preparation

A technology of cycloviral buxicine and salt preparation, which is applied in the field of cycloviral buxicine D salt preparation, which can solve the problems of long time to reach the peak blood concentration, slow oral onset of effect, difficulty in treating severe patients and patients with dysphagia, etc.

Inactive Publication Date: 2003-08-13
西藏易明西雅医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is only Huangyangning Tablets on the market, which has a slow onset of oral effect and a long time to reach the peak blood concentration. It is mostly used in mild to moderate patients clinically, and it is not easy to treat severe patients and patients with dysphagia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0066] (1), Huowei Buxusing D (Huyangning) Glucose Injection

[0067] 1. Prescription:

[0068] Cyclovitamin D 20mg

[0069] Glucose 50g

[0070] Add water for injection to 1000ml

[0071] Proper amount of hydrochloric acid or phosphoric acid

[0072] 2. Preparation process

[0073] 2.1 Preparations: Infusion bottles, rubber stoppers, and polyester liners are processed according to routine procedures and set aside; pipes and containers are cleaned and set aside.

[0074] 2.2 Take glucose, add water for injection to 1 / 5 of the full amount, add activated carbon (2 / 10,000 g / ml) and boil for 15 minutes, filter out the activated carbon, pump it into the diluted tank, add water for injection to the full amount, add activated carbon (10,000 g / ml) bis g / ml), 70-80°C, add the prescribed amount of cyclovir buxicine D, keep warm and stir for 15 minutes; adjust the pH.

[0075] 2.3 Measure the pH value of the solution to 4.0-5.0.

[0076] 2.4 Determination of the content of the solut...

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PUM

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Abstract

A cyclovirobuxine D salt, its injection for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease and angine pectoris, its application and its preparing process are disclosed. Said injection is prepared from cyclovirobuxine D, hydrochloric acid or phosphoric acid, and glycose, sodium chloride, or mannitol.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine, and more specifically relates to a preparation of cyclovirboxine D salt. Background technique [0002] Coronary heart disease is a common cardiovascular disease and one of the most important diseases affecting human health. The incidence of coronary heart disease increases with age. It is a common and frequently-occurring disease in the middle-aged and elderly people. [0003] Cyclovitamin D (Buxus Ning) is an effective drug for treating coronary heart disease and angina pectoris. Cycloviral Buxus D is an alkaloid monomer extracted and refined from the Buxus family plant Buxus microphylla and its genus plants. It is a steroidal alkaloid , the molecular formula is C 26 h 46 N 20 , According to literature reports, ring-dimensional buxicine D, buloxine, boxine I, boxicine, boxyrin, boxyline D, and cyclo-evergreen boxwood D are all the same monomer compound. So far, there is only Huangyangning Ta...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61P9/10C07J7/00
Inventor 曹明成
Owner 西藏易明西雅医药科技股份有限公司
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