Thrombosis resisting composition

Abstract

The thrombosis resisting composition consists of thromboxane A2(TXA2) synthetase inhibitor, thrombolytic medicine and / or thrombocyte resisting medicine; and can dissolving thrombus. The composition is obviously superior to single thromboxane A2(TXA2) synthetase inhibitor, and has high effect of preventing and treating thrombus diseases, small dosage and less side effect. Both extracorporeal and intracorporeal experiments shows that the composition has excellent direct thrombus dissolving effect and thrombocyte aggregation inhibiting effect. When the composition of sodium Ozagrel is used in treating acute cerebral thrombus, the clinical total effective rate is 100% and side effect originating rate is 2.1%. While only sodium Ozagrel is used, the corresponding data is 49.2% and 7.6% separately.

Description

Technical field

[0001] The invention relates to an antithrombotic composition, which is mainly used for the treatment and prevention of cerebrovascular diseases. Background technique

[0002] Cardiovascular and cerebrovascular diseases are diseases that seriously affect human health, and are also one of the diseases with higher morbidity and mortality. Among them, cerebrovascular disease has the highest mortality and disability rate, and its onset age tends to be younger. In view of this, it is urgent to develop efficient and safe drugs for the prevention and treatment of such diseases.

[0003] thromboxane A 2 (TXA 2 ) synthetase inhibitors, which have been used to treat acute cerebral thrombosis (such as Ozagrel Sodium, Ozagrel Sodium), but because they can only prevent thrombus formation, they have no direct effect on the formation of thrombus, so the onset is slow (generally Effective after 2 days of medication), the effective rate is low (data show that its effective...