The invention belongs to the technical field of freeze-dried
powder needle preparation and relates to a small-size
sodium ozagrel freeze-dried
powder needle as well as a preparation method and a production device thereof. The small-size
sodium ozagrel freeze-dried
powder needle is characterized in that
sodium ozagrel freeze-dried powder is filled into a 7ml
pipe penicillin bottle; and the content of
sodium ozagrel in the
sodium ozagrel freeze-dried powder needle is 20mg, 40mg or 80mg. The preparation method comprises the following steps of: before preparation, washing the device by a
metal complexing agent firstly and then by injection water, and meanwhile, introducing
nitrogen; reacting the
sodium ozagrel,
sodium hydroxide and an auxiliary material; after reaction, adding
active carbon; decarbonizing and filtering by a
titanium rod, and then carrying out fine filtering; and then filling the powder into the 7ml
pipe penicillin bottle, and carrying out freeze-
drying, pressing and blocking, as well as cover rolling to obtain the product. According to the small-size sodium ozagrel freeze-dried powder needle as well as the preparation method and the production device thereof disclosed by the invention, a product process is optimized so that the size of the sodium ozagrel freeze-dried powder needle is reduced, the yield of the product is improved, and the packaging and transporting cost is reduced; and as the device is washed by the
metal complexing agent, the quality of the product is improved and the medication safety is guaranteed.