Method for preparing ozagrel sodium crystal

Abstract

The invention relates to a simple technical process used for preparing high-pure ozagrel sodium crystal. The process basically includes the following steps: the raw ozagrel sodium is added into ethanol and then heated for dissolving; active carbon is added for decoloring and filtering is carried out under the heated condition; the filtrate is filtered in a refined way by a microfiltration membrane, collected, heated first and then cooled slowerly; and the temperature is controlled to be 25 DEG C to 60 DEG C for temperature-preservation crystallization and then the temperature is reduced slowly and cooled for crystallization; finally the crystal is collected. The crystal prepared by the method is high in purity and yielding and low in impurity content; therefore the therapy effect of the product is effectively enhanced and the cost is reduced simultaneously.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a crystallization process of medicinal compound ozagrel sodium. Background technique

[0002] The chemical name of the imidazole derivative Sodium Ozagrel is [(E)-p-(imidazol-1-ylmethyl)sodium cinnamate] or (E)-3-[p-(1H-imidazole- Sodium 1-methyl)phenyl]-2-acrylate. It is a highly effective and powerful inhibitor of thromboxane (TXA 2) synthase, which can specifically inhibit thromboxane synthase, reduce the production of TXA 2, and promote the production of PGI 2; it is researched and developed as a COX synthase inhibitor An active pharmaceutical ingredient for the improvement of cerebral vasospasm after subarachnoid hemorrhage and its accompanying cerebral ischemic symptoms and cerebral thrombosis (acute phase) accompanying movement disorders.

[0003] In the existing ozagrel preparation method, the crystallization process during refining is only to dissolve the ...