New ozagrel sodium compound and medicinal composition thereof

The technology of sodium ozagrel and compound is applied in the field of new sodium ozagrel and pharmaceutical compositions thereof, and can solve the problems of colored spots, color blocks, poor resolubility of lyophilized powder for injection, suspended particles and the like in solution, Achieving the effect of good shape, good resolubility and good appearance
CN102276533BInactive Publication Date: 2012-08-01周晓东
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
周晓东
Publication Date
2012-08-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a new ozagrel sodium compound and a medicinal composition thereof. Ozagrel sodium is a crystal which is obtained by measuring by using u-K alpha rays and has characteristic peaks at 2 theta of 8.7 degrees, 10.3 degrees, 12.4 degrees, 16.2 degrees, 16.8 degrees, 19.2 degrees, 20.0 degrees, 20.7 degrees, 22.0 degrees, 22.9 degrees and 23.7 degrees during X-ray powder diffraction. The invention also relates to the medicinal composition for the ozagrel sodium compound. The medicinal composition comprises a freeze-dried powder injection or a water injection. The prepared freeze-dried powder injection has a good form, and is high in redissolution and stability, and the state of the prepared water injection is good and the prepared water injection has high stability.
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Description

technical field

[0001] The present invention relates to a new ozagrel sodium compound and its pharmaceutical composition. Background technique

[0002] Cardiovascular and cerebrovascular diseases are diseases that seriously affect human life and health, and are also one of the diseases with high morbidity and mortality. Among them, cerebrovascular diseases occupy an important position in cardiovascular and cerebrovascular diseases. According to reports, there are as many as 1.5 million first-time cerebrovascular diseases in my country every year, and it has become the second largest disease that seriously affects the health of our people.

[0003] Sodium ozagrel is a thromboxane synthase inhibitor, which can inhibit the generation of TXA2, has anti-platelet aggregation and blood vessel expansion effects, can inhibit cerebral thrombosis and cerebral vasospasm, and improve movement disorders in the acute stage of cerebral thrombosis. Clinically, it is widely used in the treat...

Claims

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