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Method for high resolution magnetic resonance analysis using magic angle technique

A magnetic resonance and magic angle technology, which is applied in the fields of nuclear magnetic resonance analysis, material analysis through resonance, magnetic resonance measurement, etc., can solve problems that have not been studied in depth

Inactive Publication Date: 2004-08-25
BATTELLE MEMORIAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method has never been studied in depth

Method used

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  • Method for high resolution magnetic resonance analysis using magic angle technique
  • Method for high resolution magnetic resonance analysis using magic angle technique
  • Method for high resolution magnetic resonance analysis using magic angle technique

Examples

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example 1

[0097] Sample preparation

[0098] Fresh tissues were excised from four mice. They were genetic mutant mice produced by crossing 129 / SvJ mice and C57BI / 6J mice. The mice used carry hereditary hemochromatosis, which is a single genetic mutation that causes too much iron to be deposited in the tissues if too much iron is provided in the rat’s ration. If the rations provided to these rats contained normal iron content, the tissue analysis results were normal. Cut the 45-day-old male and female mice weighing 20 grams from the neck, quickly separate the tissue, and quickly analyze it (brain and liver), or store the tissue at 2°C for two to four hours before analysis (Kidney, heart and hip area). Put the tissue into a pen-type rotating machine with an outer diameter of 7.5-mm and an inner diameter of 5-mm. This kind of rotation is available on the market, produced by Chemagnetic Inc., and the tissue is placed in two special features in the center of the rotating machine. Between the flu...

example 2

[0109] Sample preparation

[0110] The experiment described below was performed on excised mouse liver tissue, which was obtained from Fisher 344 male mice. The reason for choosing the liver was that it was found that the proton lines obtained in a static sample were so wide that it was difficult or even impossible to distinguish different metabolites. Before removing the liver from the animal, use CO 2 Suffocated the mouse and died. Before putting the sample into the NMR rotating machine, about 200 mg of liver was cut into small pieces (approximately 2 mm in size), and a part of it was randomly selected and placed in the rotating machine to provide a more or less isotropic sample.

[0111] Two different sample preparation methods were used. In the first case, the excised liver is placed in the NMR rotating machine immediately after the excision. Therefore, the results obtained from such samples can be regarded as expected in vivo test results. In the second case, use Bollard et a...

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Abstract

A method of performing a magnetic resonance analysis of a biological object that includes placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54 DEG 44' relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. The object may be reoriented about the magic angle axis between three predetermined positions that are related to each other by 120 DEG. The main magnetic field may be rotated mechanically or electronically. Methods for magnetic resonance imaging of the object are also described.

Description

[0001] Priority statement [0002] This application is a continuation application of a part of US Patent 09 / 803,381 filed in September 2001, and 09 / 803,381 is incorporated herein by reference. [0003] Government support statement [0004] The present invention was made with the support of the U.S. government under the contract DE-AC0676RLO 1830 awarded by the U.S. Department of Energy. Technical field [0005] This announcement relates to the analysis of magnetic resonance (MR), specifically to the magnetic resonance spectroscopy (MRS) and imaging (MRI) of biological objects. Background technique [0006] Certain selected groups of nuclei exhibit the phenomenon of magnetic resonance, which is caused by the movement of the nuclear magnetic field in these nuclei (called "gyromagnetic" nuclei). When the magnetic gyro nucleus is placed in a strong, balanced and stable magnetic field (the so-called "external field", here referred to as the "static" magnetic field), it will produce pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/20G01N24/08G01N33/483G01R33/30G01R33/465G01R33/54
CPCG01R33/307G01R33/54
Inventor 罗伯特·A·温德胡建志
Owner BATTELLE MEMORIAL INST
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