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Injection liquid for treating heart brain blood vessel disease and its prearation method

A technology for injections and injections, which is applied to cardiovascular system diseases, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as rebound, lack of safe and quick-acting drugs, and low solubility of monoterpene components.

Inactive Publication Date: 2005-08-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these drugs are expensive, have obvious side effects, and generally have the disadvantage of rebound after drug withdrawal
[0004] In recent years, especially in my country, people have intensified the research on the treatment of cardiovascular and cerebrovascular diseases with traditional Chinese medicine, mainly screening from traditional prescriptions, and achieved certain achievements. Many varieties have been used in clinical practice, and oral medicines include compound prescriptions. Danshen Tablets, Compound Danshen Dropping Pills, etc. Among them, Compound Danshen Dropping Pills are widely used in clinical practice due to their good curative effect, but because they are solid preparations, there are shortcomings that cannot be overcome by solid preparations.
Only Xuesaitong, Compound Danshen Injection (Danshen, Xiangfu), Danshen Injection, Ligustrazine Injection, etc. are available for injection, but the curative effects are not satisfactory
The borneol in this prescription is widely used clinically, but because borneol, camphor and other monoterpenes in borneol have low solubility in water, borneol is a small-molecule fat-soluble monoterpene, and currently only pills can be produced , tablets and other solid preparations have not been able to be applied to liquid preparations such as injections
The 2000 edition of "Chinese Pharmacopoeia" discloses the prescription of Compound Danshen Dripping Pills. Chinese patent 01136155 discloses a drug for the prevention and treatment of coronary heart disease angina pectoris, its preparation method and other uses. It can only be prepared as a solid preparation - Compound Danshen Drops Pills, which cannot be made into injections;
[0005] Therefore, it can be considered that the current incidence of clinical cardiovascular and cerebrovascular diseases is very high, but there is a lack of safe and quick-acting drugs. If the compound Danshen dripping pills are modified into injections, it will be a good news for the whole world.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0176] Danshen 49.0g Panax notoginseng 50g borneol 1g

[0177] (1) Danshen, add 12 times the amount of water and decoct 3 times, each decocting for 3 hours; combine the decoction liquid, concentrate; add ethanol to precipitate the medicinal liquid when it is slightly cooled to room temperature, so that the alcohol content reaches 85%, and refrigerate After 24 hours, filter, the filtrate is decompressed to recover ethanol, add water for injection to 1g of Danshen crude drug per 1ml, adjust the pH to 2 with hydrochloric acid, refrigerate for 24 hours, filter, extract the filtrate with ethyl acetate, recover ethyl acetate, Dissolve the extract with water for injection, filter, adjust the pH to 8 with NaOH, add 0.1% activated carbon, heat and boil for 30 minutes, filter to obtain the intermediate of the water-soluble extract of Danshen;

[0178] (2) Take Radix Notoginseng, extract 3 times with 60% ethanol under reflux, each time for 2 hours; combine alcohol reflux liquid, reclaim ...

Embodiment 2

[0181] Danshen 49g Sanqi 48.3g borneol 2.7g

[0182] (1) Salvia, add 5 times the amount of water and decoct once, 0.5 hours each time; combine the decoction liquid and concentrate; add ethanol to precipitate the medicinal liquid when it is slightly cooled to room temperature, so that the alcohol content reaches 75%, and refrigerate After 24 hours, filter, the filtrate is decompressed to recover ethanol, add water for injection to 5g of Danshen crude drug per 1ml, adjust the pH to 3 with hydrochloric acid, refrigerate for 24 hours, filter, extract the filtrate with ethyl acetate, recover ethyl acetate, Dissolve the extract with water for injection, filter, adjust the pH to 5 with NaOH, add 0.1% activated carbon, heat and boil for 30 minutes, filter to obtain the intermediate of the water-soluble extract of Danshen;

[0183] (2) Take Radix Notoginseng, extract twice with 75% ethanol under reflux, each time for 3 hours; combine the alcohol reflux liquid, reclaim the ethanol under...

Embodiment 3

[0186] Salvia 93.6g Panax notoginseng 6.2g Borneol 0.2g

[0187] (1) Salvia, add 8 times the amount of water to decoct 5 times, each time decocting for 1 hour; combine the decoction liquid, concentrate; add ethanol to precipitate the medicinal liquid when it is slightly cooled to room temperature, so that the alcohol content reaches 60%, and refrigerate After 24 hours, filter, and recover ethanol from the filtrate under reduced pressure, add water for injection to 2 g of Danshen crude drug per 1 ml, adjust the pH to 3 with hydrochloric acid, refrigerate for 24 hours, filter, extract the filtrate with ethyl acetate, recover ethyl acetate, Dissolve the extract with water for injection, filter, adjust the pH to 7 with NaOH, add 0.1% activated carbon, heat and boil for 30 minutes, filter to obtain the intermediate of the water-soluble extract of Danshen;

[0188] (2) Take Radix Notoginseng, extract 6 times with 40% ethanol under reflux, each time for 0.5 hours; combine the alcohol...

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PUM

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Abstract

A Chinese medicine in the form of injection of treating cardiovascular and cerebrovascular is prepared from red sage root, notoginseng, and borneol. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine injection for treating cardiovascular and cerebrovascular diseases, in particular to an injection prepared by taking Chinese medicinal materials salvia miltiorrhiza, notoginseng and borneol as raw materials, and also relates to a preparation method of the medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are currently the number one cause of death in industrialized countries, and their incidence rate is even higher than that of cancer. In the United States alone, the annual number of patients is as high as 1 million. With the progress of our country's society and the improvement of people's living standards, cardiovascular and cerebrovascular diseases have become one of the main diseases that threaten the physical and mental health of our people. Therefore, the prevention and treatment of cardiovascular and cerebrovascular diseases have extremely important practica...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61P9/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION