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Medicinal composition contg. IDV and valproic acid or salts thereof

A technology of indinavir and valproic acid, which is applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, and can solve problems such as the formation of immature non-infectious virus particles

Inactive Publication Date: 2006-06-28
北京明新高科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This inhibition blocks cleavage of viral aggregated proteins, leading to the formation of immature, non-infectious virions

Method used

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  • Medicinal composition contg. IDV and valproic acid or salts thereof
  • Medicinal composition contg. IDV and valproic acid or salts thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 2. Preparation method:

[0040] Pass the indinavir sulfate, valproic acid, lactose, microcrystalline cellulose and CMC-Na of the above prescription amount through a 80 mesh sieve, mix evenly, pass through a 40 mesh sieve, add an appropriate amount of binder 95% ethanol solution to make a soft material , 18-mesh sieve granulation, drying at 80 ° C, 18-mesh sieve granulation, adding magnesium stearate as a lubricant, mixing, tabletting, each tablet weighs 0.75g.

Embodiment 2

[0043] 2. Preparation method

[0044] The indinavir sulfate, sodium valproate, pregelatinized starch, microcrystalline cellulose and CMS-Na of above-mentioned recipe quantity are crossed 80 mesh sieves, mix homogeneously, cross 40 mesh sieves, add binding agent 95% ethanol and Appropriate amount of 2% Tween solution to make soft material, granulate with 18-mesh sieve, dry at 50-60°C, granulate with 18-mesh sieve, add magnesium stearate as lubricant, mix well, compress into tablets, each tablet weighs 0.80g.

Embodiment 3

[0047] 2. Preparation method

[0048] Pass the indinavir, sodium valproate, pregelatinized starch, lactose, and CMS-Na in the above prescription amount through a 80-mesh sieve, mix well, pass through a 40-mesh sieve, add binder 95% ethanol and 1% PVP solution Appropriate amount of soft material, granulated with 18-mesh sieve, dried at 50-60°C, granulated with 18-mesh sieve, added magnesium stearate as lubricant, mixed evenly, pressed into tablets, each tablet weighed 0.55g.

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Abstract

A composite medicine for treating AIDS and ARC and killing HIV is prepared from the Yindinawei (0.1-95 Wt%), propylphocenic acid or its salt (10.-95), and medicinal auxiliary (4-98.9).

Description

technical field [0001] The invention relates to a pharmaceutical composition containing indinavir and valproic acid or a salt thereof for treating immunodeficiency syndrome caused by human immunodeficiency virus infection. Background technique [0002] Aquired immunodeficiency syndrome (AIDS), commonly known as AIDS, caused by human immunodeficiency virus (human immunodeficiency virus, HIV) infection, is currently widespread worldwide and has become a major public health and social problem that has attracted worldwide attention. Now it is generally believed that HIV is the cause of AIDS and AIDS-related syndrome (AIDS-related complex, ARC). Not only is HIV the leading cause of AIDS, but HIV infection alone often causes over time such profound immunodeficiency that the patient dies. Due to public attention, HIV has also become one of the most well-studied viruses in history. Despite scientists' efforts, there is still no effective or even satisfactory treatment for this fat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K31/19A61K47/02A61K47/06A61K47/30A61P31/18
Inventor 张春颖张大德王秀英王秀云王淑娟
Owner 北京明新高科技发展有限公司
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