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Pharmaceutical composition containing nevirapine and valproic acid or its salt

A technology of nevirapine and valproic acid is applied in the field of pharmaceutical compositions containing nevirapine and valproic acid or a salt thereof, and can solve problems such as inability to HIV virus

Inactive Publication Date: 2006-06-21
北京明新高科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention utilizes the new medicinal composition that commonly used first-line anti-AIDS drug nevirapine and valproic acid or its salt are formed, in order to overcome the deficiency that common anti-AIDS drug cannot "awaken" the HIV virus in the CD4+ cell of dormant state, simultaneously provides A relatively inexpensive new anti-AIDS dual combination drug

Method used

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  • Pharmaceutical composition containing nevirapine and valproic acid or its salt
  • Pharmaceutical composition containing nevirapine and valproic acid or its salt

Examples

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Embodiment 1

[0042] 2. Preparation method:

[0043] Pass the nevirapine, valproic acid, lactose and MCC of above-mentioned prescription quantity through 100 mesh sieves, mix uniformly, cross 60 mesh sieves, add binder PVP (1% aqueous solution) and Tween-80 (1% dehydrated alcohol) appropriate amount Make soft material, granulate with 20-mesh sieve, dry at 80°C, sieve with 20-mesh sieve, add colloidal silicon dioxide and stearic acid as lubricants, mix well, and press into tablets, each tablet weighs 0.80g.

Embodiment 2

[0046] 2. Preparation method

[0047] The nevirapine, sodium valproate, pregelatinized starch and MCC of above-mentioned recipe quantity are crossed 100 mesh sieves, mix uniformly, cross 60 mesh sieves, add binder 95% ethanol and 2% Tween solution to make soft material in right amount, 20 Granulate with a mesh sieve, dry at 50-60°C, granulate with a 20-mesh sieve, add colloidal silicon dioxide and magnesium stearate as lubricants, mix well, and press into tablets. Each tablet weighs 0.60g.

Embodiment 3

[0050] 2. Preparation method

[0051] Pass the above prescription amount of nevirapine, valproic acid, sucrose, lactose and cCMS through a 100-mesh sieve, mix well, pass through a 60-mesh sieve, add an appropriate amount of binder 95% ethanol and 2% Tween (1% absolute ethanol) solution Make soft material, granulate with 20-mesh sieve, dry at 50-60°C, granulate with 20-mesh sieve, add magnesium stearate and micropowder silica gel as lubricant, mix well, press into tablets, each tablet weighs 0.40g.

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Abstract

The present invention is the therapeutic composition of Nevirapine and valproic acid or its salt. The medicinal composition consists of Nevirapine 0.1-95 wt%, valproic acid or its salt 1.0-95 wt% and medicinal supplementary material 4-98.9 wt%. Each unit of the medicine preparation includes Nevirapine 100-300 mg, valproic acid or its salt 50-500 mg and pharmaceutically acceptable supplementary material in 15-40 wt% preferably. The medicinal composition is used in treating HIV infection, especially treating AIDS or ARC of AIDS. The medicinal composition of Nevirapine and valproic acid or its salt is superior to anti-AIDS medicine Nevirapine and valproic acid or its salt, which can not 'awake' HIV inside CD4+ cell in dormancy state, and has relatively low cost.

Description

Technical field: [0001] The invention relates to a medicinal composition containing nevirapine and valproic acid or a salt thereof for treating immunodeficiency syndrome caused by human immunodeficiency virus infection. Background technique: [0002] Aquired immunodeficiency syndrome (AIDS), commonly known as AIDS, caused by human immunodeficiency virus (human immunodeficiency virus, HIV) infection, is currently widespread worldwide and has become a major public health and social problem that has attracted worldwide attention. Now it is generally believed that HIV is the cause of AIDS and AIDS-related syndrome (AIDS-related complex, ARC). Not only is HIV the leading cause of AIDS, but HIV infection alone often causes over time such profound immunodeficiency that the patient dies. Due to public attention, HIV has also become one of the most well-studied viruses in history. Despite scientists' efforts, there is still no effective or even satisfactory treatment for this fatal...

Claims

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Application Information

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IPC IPC(8): A61K31/551A61K31/19A61P31/18
Inventor 王秀英张春颖张大德王秀云肖佳普
Owner 北京明新高科技发展有限公司
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