Prevention of addiction in pain management

a technology for pain management and addiction, applied in the field of composition for treating pain in mammals, can solve the problems of inability to quantify the adequacy of pain control regimens, poor treatment, and one of the most troubling and difficult areas of medicine, and achieve the effect of reducing the concentration of da in the na

Inactive Publication Date: 2002-12-12
BROOKHAVEN SCI ASSOCS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

0049] .gamma.-Amino butyric acid (GABA)ergic neurons in the NAcc and ventral pallidum project onto DA neurons in the VTA. Pharmacologic and electrophysiologic studies indicate these projections are inhibitory. Inhibition of VTA-DA neurons is likely the result of GABA.sub.B receptor st

Problems solved by technology

For many years, the treatment of postoperative pain and those conditions associated with chronic pain have been one of the most troubling and difficult areas of medicine.
In general treatment has been so poor that laws have been enacted to ensure a patient's right to adequate pain management.
A major issue in pain management comes from the inability to quantify the adequacy of a pain control regimen.
The clinical issues are complex, but it is cl

Method used

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  • Prevention of addiction in pain management

Examples

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Effect test

example 1

[0074] The effects of increased endogenous GABA activity on morphine-induced extracellular DA concentrations in the nucleus accumbens (NAcc) of freely moving rats was explored.

[0075] All animals were used under an IACUC-approved protocol and with strict adherence to the NIH guidelines. Adult male Sprague-Dawley rats (200-300 g, Taconic Farms), housed in the animals care facility under 12:12 light / dark conditions, were placed into 6 groups (n=3-6), anesthetized and siliconized guide cannulae were stereotactically implanted into the right NAcc (2.0 mm anterior and 1.0 mm lateral to bregms, and 7.0 mm ventral to the cortical surface) and prefrontal cortex (PFC) at least 4 days prior to study. Microdialysis probes (2.0 mm, Bioanalytical Systems, BAS, West Lafayette, Ind.) were positioned within the guide cannulae and artificial cerebrospinal fluid (ACSF, 155.0 mM NA.sup.-, 1.1 mM Ca.sup.2-, 2.9 mM K.sup.-, 132.76 mM C1.sup.-, and 0.83 mM Mg.sup.2-) was administered through the probe usi...

example 2

[0079] The effect of GVG on the analgesic potency of morphine in male Sprague-Dawley rats was examined using the hot plate test. In this paradigm, animals are treated and placed on a hot plate at a temperature of 53 degrees Centigrade and the latency to licking of one of the forepaws was measured. This test is used as screen for agents that have moderate to significant analgesic action as these drugs will increase latency to forepaw licking.

[0080] The rats were treated with either vehicle or GVG 2.5 hours prior to receiving either vehicle or morphine. Animals were given either vehicle or morphine 30 minutes prior to placing them on a hot plate at a constant temperature of 53 degrees Centigrade. Analgesic potency was assessed by measuring the latency to forepaw licking after placement on the hot plate. A total of 10 rats were examined for each treatment group. Each value represents the latency in seconds to forepaw licking .+-.S.E.M. The results are set forth in Table 1.

1TABLE 1 Pret...

example 3

[0082] Heroin-induced conditioned place preference was then examined. Heroin is an effective analgesic, similar to morphine.

[0083] In all rodent studies, male Sprague-Dawley rats were used (200-225 g, Taconic farms, Germantown, N.Y.). Animals were allowed to acclimate to the animal housing facility for at least 5 days prior to beginning the experiments. Conditioned place preference (CPP) chambers were used as previously described (Lepore et al., 1995), except instead of one chamber being entirely white and the other black, one chamber was entirely light blue with a stainless steel floor and the second chamber was light blue with horizontal black stripes (2.5 cm wide) spaced 3.8 cm apart with a smooth plexiglass floor. In all CPP studies with GVG, the saline volume was (1 ml / kg), and the heroin doses were 1.5 mg / kg. The saline, heroin and GVG were all injected intraperitonealy (i.p.). The conditioning procedure for the acquisition phase consisted of 12 sessions carried out consecutiv...

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Abstract

The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic. The invention also includes a method for reducing or eliminating the addictive

Description

[0002] This invention relates to the prevention of addiction. More specifically, the invention relates to the administration of a compound to prevent addiction to analgesics often administered in pain management.[0003] For many years, the treatment of postoperative pain and those conditions associated with chronic pain have been one of the most troubling and difficult areas of medicine. In general treatment has been so poor that laws have been enacted to ensure a patient's right to adequate pain management.[0004] A major issue in pain management comes from the inability to quantify the adequacy of a pain control regimen. The clinical issues are complex, but it is clear that inadequate pain control leads to excessive morbidity and poor clinical outcomes.[0005] It has long been known that exact pain control will improve the clinical outcome and be associated with little or no addiction liability. In a typical clinical situation, however, exact pain control is almost impossible to atta...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K31/165A61K31/19A61K31/195A61K31/357A61K31/485A61K45/06A61P25/04A61P29/00A61P43/00
CPCA61K31/485A61K45/06A61K2300/00A61P25/04A61P25/30A61P25/36A61P29/00A61P39/02A61P43/00A61K31/197
Inventor DEWEY, STEPHEN L.BRODIE, JONATHAN D.ASHBY, CHARLES R. JR.
Owner BROOKHAVEN SCI ASSOCS
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