Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods for enhancing wound healing

a wound healing and wound technology, applied in the field of wound healing enhancement, can solve the problems of increasing skin tension and affecting wound healing, affecting wound healing, and etiology of skin tension lines, and achieves the effects of reducing scar formation, reducing skin tension, and reducing scar formation

Inactive Publication Date: 2005-08-11
MAYO FOUND FOR MEDICAL EDUCATION & RES
View PDF7 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a new therapy for managing wounds by eliminating tension. It involves injecting a chemodenervating agent to paralyze muscles that can apply tension on the wound, resulting in better healing with minimal scar development. This therapy also allows for early immobilization in elective procedures, improving the cosmetic result. The invention includes a method for treating a patient with a wound by administering a chemodenervating agent, a local anesthetic, and / or a local vasoconstrictive agent. The invention also includes a composition containing a chemodenervating agent, a local anesthetic, and / or a local vasoconstrictive agent. The technical effects of the invention include improved wound healing, reduced scar development, and improved cosmetic results.

Problems solved by technology

The etiology of skin tension lines, first described more than a century ago, has been subject to controversy over the years.
Increased skin tension has a negative effect on wound healing, causing hypertrophic scars or wound dehiscence.
As a consequence, extracellular deposition of collagen and glycosaminoglycans can intensify and lead to hypertrophic scars.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods for enhancing wound healing

Examples

Experimental program
Comparison scheme
Effect test

example 1

Enhanced Wound Healing by Injection of a Chemodenervating Agent in Monkeys

[0027] In order to closely mimic the effects of muscle activity on human facial skin wounds, the use of an appropriate animal model was mandatory. Due to extensive skin laxity and inadequate mimetic musculature, established models like rats, pigs, and horses, were not ideal for this purpose. Cynomolgus macaque monkeys (Macaca fascicularis) were chosen as a model since the anatomy of their cranio facial and cutaneous anatomy resembles that of humans.

[0028] The study was approved by the Institutional Committee of Animal Care and Use at the Mayo Clinic and the animals were housed, cared for, and fed in compliance with the institutional guidelines. No animal was sacrificed. All procedures were performed with anesthesia consisting of Ketamine at 20 mg / kg IM (Ketaset®, Fort Dodge), Xylazine at 0.5 mg / kg IM (Rompun®, Bayer), and Isoflurane at 1% (Isoflurane®, Abbott).

[0029] The forehead was chosen for the excision...

example 2

Enhanced Wound Healing by Botulinum Toxin A Injection in Humans

[0035] A male patient (26 years of age, 82 kg) underwent scar revision excision surgery. The scar was located on the forehead approximately 2 cm lateral of the midline on the left, and approximately 3 cm cranial to the most superior extension of the orbital rim. Its direction was horizontal, giving it a favorable position relative to the wrinkle lines. The scar was a result of a trauma at age seven, and was closed at a tertiary referral center at the time.

[0036] The patient was placed in a supine position, and 5 ml of 0.5% lidocaine with 1:200,000 epinephrine was locally injected. The scar was excised and bleeding was controlled with monopolar cautery. Botulinum toxin A was injected (10 units) into the frontalis muscle under direct vision fanning out from the wound. The wound was closed using 6-0 Vicryl for deep and 6-0 Nylon for superficial sutures. An additional 7.5 units of botulinum toxin A were injected into the p...

example 3

Evaluation of Scars from Patients Injected with a Chemodenervating Agent Alone or in Combination with a Local Anesthetic

[0038] Healthy volunteers were informed about potential risks and side effects of the treatment. Formal written informed consent was obtained in accordance with the Mayo Institutional Review Board regulations. Prior to enrollment in the study, symmetry of frontalis, procerus, and corrugator supercilii function was assessed and subjects were only included in the study if there was no functional asymmetry present. The forehead of the subjects was divided by the midline into two symmetric sides, one serving as the control and the other as the experiment side. The side of the forehead which was to serve as control was determined randomly, and was injected with Botulinum Toxin A (Botox) reconstituted in 0.9% saline. The experimental side was injected with Botulinum Toxin A reconstituted in 1% or 2% lidocaine with 1:100,000 epinephrine. The combination of these agents w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
muscle tensionaaaaaaaaaa
tensionaaaaaaaaaa
muscular tensionaaaaaaaaaa
Login to View More

Abstract

A method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is illustrated by detailing the mean differences of the scores of the paired experimental and control scars across three observers.

Description

TECHNICAL FIELD [0001] The invention relates to a method for enhancing wound healing. BACKGROUND OF THE INVENTION [0002] Immobilization is a basic therapeutic principle in wound healing, common to the treatment of lesions of all kinds. Casts, plates, and sutures minimize the negative effects of muscle tension on healing tissues. Since tension is one of the chief factors determining the degree of scar formation, this principle also holds true in skin lesions. The carefully-planned execution of an elective skin incision frequently achieves the best aesthetic result. [0003] Surgeons have been seeking techniques and methods to reduce excessive scar formation, especially in the face. Many approaches have been undertaken to overcome the negative influence of muscular tension on the wound healing process, including various suture techniques, steroid injections, undermining wound edges, and placing incisions in a line parallel to relaxed skin tension lines (RSTLs). [0004] The etiology of sk...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/137A61K31/167A61K31/445A61K45/00A61K31/505A61K31/519A61K31/529A61K38/00A61K38/16A61P17/02
CPCA61K31/335A61K31/505A61K31/519A61K31/529A61K38/164A61K38/4886A61K2300/00A61P17/02A61K39/08
Inventor GASSNER, HOLGER G.SHERRIS, DAVID A.
Owner MAYO FOUND FOR MEDICAL EDUCATION & RES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com