Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof

a technology of triggering receptor and myeloid cells, applied in the field of new activating receptors, can solve the problems of tissue damage and septic shock, and achieve the effect of strong upregulation of ccr7
US20050260670A1Inactive Publication Date: 2005-11-24COLONNA MARCO +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
COLONNA MARCO
Publication Date
2005-11-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-beta. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
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Description

[0001] This application is entitled to and claims priority benefit to U.S. provisional application Ser. No. 60 / 277,238, filed Mar. 20, 2001, which is incorporated herein by reference in its entirety.1. INTRODUCTION

[0002] This invention relates generally to new activating receptors of the Ig super-family expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells) which are involved in immune and inflammatory responses. Specifically, this invention relates to two (2) members of TREMs: TREM-1 and TREM-2.2. BACKGROUND OF THE INVENTION

[0003] Inflammatory responses to bacterial and fungal infections are primarily mediated by neutrophils and monocytes (Medzhitov, R. & Janeway, C., Jr., 2000, N. Engl. J. Med. 343:338-44; Hoffmann, J. A., Kafatos, F. C., Janeway, C. A. & Ezekowitz, R. A., 1999, Science 284:1313-8). These cells express pattern recognition receptors (PRR) which recognize conserved molecular structures shared by groups of microorganisms (Adere...

Claims

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