Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof

a technology of myeloid cells and receptors, applied in the field of new receptor trem (triggering receptor expressed on myeloid cells) and its use, can solve the problems of tissue damage and septic shock
US20160251434A1Inactive Publication Date: 2016-09-01NOVO NORDISK AS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NOVO NORDISK AS
Publication Date
2016-09-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel activating receptors of the lg super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
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Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 13 / 690,828, filed Nov. 30, 2012, which is a continuation-in-part of U.S. patent application Ser. No. 13 / 560,612, filed Jul. 27, 2012, now abandoned, which is a continuation of U.S. patent application Ser. No. 12 / 687,038, filed Jan. 13, 2010, now abandoned, which is a continuation of U.S. patent application Ser. No. 11 / 188,281, filed Jul. 25, 2005, now abandoned, which is a continuation of U.S. patent application Ser. No. 10 / 103,423, filed Mar. 20, 2002, now abandoned, which claims priority to U.S. Provisional Patent Application No. 60 / 277,238, filed Mar. 20, 2001, all of which are incorporated herein by reference in their entirety.1. INTRODUCTION

[0002] This invention relates generally to new activating receptors of the Ig super-family expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells) which are involved in immune and in...

Claims

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