Imaging sexual response
a technology of contrast and sexual response, applied in the field of contrast-enhanced imaging of sexual response, can solve the problems of no reliable diagnostic test, no known if normal sexual function or sexual dysfunction could be measured with such types of agents, and the disadvantage of not providing an absolute measure of vaginal blood volume or blood flow
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example 1
[0068] Imaging of the genitalia was performed in four pre-menopausal and four post-menopausal healthy, sexually functional women subjects after administration of MS-325 (MS-325, EPIX Medical, Inc.). All volunteers signed an IRB-approved informed consent form for the study.
[0069] Six of the subjects received an intravenous injection of 0.05 mmol / kg of MS-325 and two received an intravenous injection of 0.02 mmol / kg of MS-325. Dynamic MRI (3D SPGR, 11 / 1.7 / 35°) of the perineum was performed on all subjects while they viewed videos containing first neutral material, then erotic material and finally neutral material via a fiberoptic audiovideo system. Each segment of neutral or erotic material was up to 15 minutes in length. Subjects also filled out questionnaires in response to the videos that had them subjectively rate their degree of sexual arousal.
[0070] Serial imaging was performed at least every 3 minutes, beginning just prior to contrast injection and continuing up to 45 minutes...
example 2
[0073] Imaging of genitalia is performed on female subjects who have or who are suspected of having sexual arousal dysfunction. The subjects receive an intravenous injection of 0.01 to 0.1 mmol / kg of MS-325. Dynamic MRI is performed as described above while they are exposed to neutral material and then erotic material. In one embodiment, the subjects view videos containing first neutral material, then erotic material and finally neutral material via a fiberoptic audiovideo system. Subjects may fill out questionnaires in response to the erotic material to allow them to subjectively rate their degree of sexual arousal.
[0074] Serial imaging is performed as described above. Signal intensity measurements over time are made of the vaginal wall and mucosa, clitoris, skeletal muscle, and femoral vein. Clitoral volume is measured at each time point. Relative regional blood volume is determined from signal intensity versus time curves and compared with subjective measures of arousal.
[0075] ...
example 3
[0076] Imaging is performed as described in Example 2. After a diagnosis of sexual arousal dysfunction has been made in a subject or group of subjects, a therapeutic compound for sexual arousal disorder is administered. The therapeutic compound may be one that is known to treat sexual arousal dysfunction or may be one that is being screened for its ability to treat sexual arousal disorder. In one embodiment, the therapeutic compound is Viagra™. After treatment with the therapeutic compound, imaging is performed again as described in Example 2. By comparing the change in clitoral blood volume and size before treatment to that after treatment, one may determine if the therapeutic compound is effective for treating sexual arousal disorder in a particular subject or group of subjects.
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