Biological tissue regenerative agent and method for preparing and using same

a biochemical and tissue technology, applied in the field of biochemical tissue regeneration agent and method for preparing and using same, can solve the problems of severe compatibility crises, immunologic problems, roadblocks to the use of platelet containing or platelet derived products, etc., and achieve the effect of suppressing active tgf- and avoiding non-homologous thrombin

Inactive Publication Date: 2006-02-23
BARRUETA ALBERTO GORROCHATEGUI +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0044] In another embodiment, the composition of the instant invention, which is normally held at an approximately physiologic pH, may have the inactive TGF-β activated by, for example only, exposing it to an acidification process. This would create a composition with effects more resembling those of compositions containing materials released by platelets during the platelet release reaction, but with the additional benefits of providing compounds normally contained in the platelet α-granules, dense bodi

Problems solved by technology

Major roadblocks to the use of platelet containing or platelet derived products have been immunologic issues.
This can be particu

Method used

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  • Biological tissue regenerative agent and method for preparing and using same
  • Biological tissue regenerative agent and method for preparing and using same
  • Biological tissue regenerative agent and method for preparing and using same

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Embodiment Construction

[0059] The method and materials of biological tissue repair of the instant invention enables a significant advance in the state of the art. The preferred embodiments of the method and materials accomplish this by new and novel arrangements of elements and methods that are configured in unique and novel ways and which demonstrate previously unavailable but preferred and desirable capabilities.

[0060] The detailed description set forth below in connection with the drawings is intended merely as a description of the presently preferred embodiments of the invention, and is not intended to represent the only form in which the present invention may be constructed or utilized. The description sets forth the designs, functions, means, and methods of implementing the invention in connection with the illustrated embodiments. It is to be understood, however, that the same or equivalent functions and features may be accomplished by different embodiments that are also intended to be encompassed ...

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Abstract

A biological tissue regenerative agent and method for preparing the same. The agent comprises the compounds that are usually found sequestered within platelets, along with platelet cytosolic components, and serum. The agent is prepared by preparing two quanta of blood. The first is clotted, the cells discarded and the serum retained. The second quantum undergoes concentration and lysis of the platelets therein, followed by recombination of the lysed platelets and platelet internal products with serum to form the agent. In a preferred embodiment, lysis of platelets is accomplished by providing an effective amount of calcium. The avoidance of a platelet release reaction and the presence of alpha-2 macroglobulin in the serum suppresses active TGF-β in the agent. The agent may be further purified and may be frozen or freeze dried for storage.

Description

REFERENCE TO RELATED DOCUMENTS [0001] This application is a continuation-in-part of a previous application filed in the United States Patent and Trademark Office Alberto Gorrochategui Barrueta, M.D.; Josu Simon Elizundia, M.D.; and Emilio Barbera-Guillem, M.D., Ph.D.; on Aug. 20, 2004, titled “Biological Tissue Regenerative Agent And Method For Preparing Same;” and given Ser. No. 10 / 923,237.TECHNICAL FIELD [0002] The present invention relates to the field of biological tissue growth and repair, particularly to a regenerative agent that enhances tissue and cell growth, repair, and transplantation, and a method for preparing and using same. BACKGROUND OF THE INVENTION [0003] Traumatic or pathological tissue injury leads to loss of biological tissue, followed by natural attempts at repair and tissue remodeling. Due to attendant failures in natural repair, human and veterinary medicine attempts to intervene in the natural repair and remodeling process via a number of modalities. This ca...

Claims

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Application Information

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IPC IPC(8): A61K35/16
CPCA61K35/16
Inventor BARRUETA, ALBERTO GORROCHATEGUIELIZUNDIA, JOSU SIMONBARBERA-GUILLEM, EMILIO
Owner BARRUETA ALBERTO GORROCHATEGUI
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