Menthol-containing preparation

Abstract

It is known that L-menthol controls smooth muscle contraction. In order to use L-menthol in practice as a digestive tract contraction inhibiting agent in digestive tract endoscopy, it is required to devise means of giving a formulation in which an L-menthol-containing formulation remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. In the present invention, an antifoaming agent is further added to a formulation for inhibiting smooth muscle contraction or a peristaltic contraction in a digestive tract containing a L-menthol emulsion having an average particle size of less than 100 nm. Thus, it is possible to obtain a formulation that remains stable over a long time, has a high light transmittance, and produces little foam when filled into a container and sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc.

Description

TECHNICAL FIELD [0001] The present invention relates to an L-menthol-containing formulation for inhibiting smooth muscle contraction or peristalsis, particularly a formulation for inhibiting digestive tract contraction, which remains stable over a long time, exhibits high light transmittance, and produces little foam when sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc. BACKGROUND ART [0002] Excessive contraction of the digestive tract during endoscopic examination of the digestive tract such as stomach and large intestine prevents correct diagnosis and allows a minute lesion such as a small-sized carcinoma to be missed. [0003] As a contraction inhibitor for endoscopic examination of the digestive tract, an anti-cholinergic agent scopolamine butylbromide (Trade name: Buscopan Injection, Nippon Boehringer Ingelheim Co., Ltd.) or glucagon has conventionally been prescribed. However scopolamine b...

AI Technical Summary

Benefits of technology

[0046] The formulation for inhibiting smooth muscle contraction, the emulsion of the invention remains stable over a long time, exhibits a high light transmittance, and causes little foam during filling in a container or in use, namely in administration. Therefore the formulation is useful as a contraction inhibitor to be used particularly in endoscopic examination of the digestive tract.

Problems solved by technology

This inhibitor formulation, however, required a relatively high content of the surfactant for transparency so that foaming occurred during filling the formulation into a container or during spraying through a tube to the affected area for endoscopic examination, and the foam made observation of the affected area difficult.

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