Medicinal composition for ophthal use containing acetylated hyaluronic acid

Inactive Publication Date: 2006-07-27
SHISEIDO CO LTD
View PDF1 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] It is an object of the present invention to provide pharmaceutical composition for

Problems solved by technology

The cause of dry eye is a reduction in lacrimal quantity or a qualitative change in the components thereof, and this disorder can result in scratching or other damage when the surface of the eye becomes dry.
Symptoms include eye pain or fatigue, increased blinking, and bloodshot eyes.
Further, bacteria may enter through a scratch and cause infection, and if the scratch is deep enough it can even affect the vision of the person.
In the case of dry eye caused by Sjogren's syndrome, in which dryness is seen over the entire body, the application of eyedrops containing hyaluronic acid is effective all by itself, but when the symptoms are severe, hyaluronic acid-containing eyedrops alone may not provide a sufficient effect, and it is sometimes necessary for the treatment to entail tear duct blockage by means of a tear duct plug.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition for ophthal use containing acetylated hyaluronic acid

Examples

Experimental program
Comparison scheme
Effect test

examples

[0027] In their research for the present invention, the inventors examined the ability of acetylated hyaluronic acid (hereinafter referred to as “AcHA”) to suppress moisture evaporation, using a soft contact lens (SCL) as a substitute for a human or animal cornea, in an attempt to apply AcHA to an ophthalmic pharmaceutical composition used for the treatment of dry eye.

Experimental Materials and Methodology

[0028] The SCLs used as a substitute cornea were Focus Dailies (disposable, 13.8 mm diameter) from Ciba Vision (Tokyo).

[0029] The SCLs used in the experiment were made from Nelfilcon A, which is a hydrogel based on a therapeutic material (polyvinyl alcohol, PVA) that has good biocompatibility and is used for surgical sutures and artificial blood vessels. This SCL retains a large amount of water (69%) and has satisfactory oxygen permeability. Accordingly, this SCL has good biocompatibility and good affinity with the cornea, making it suitable as a substitute cornea in physical p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention provides an ophthalmic pharmaceutical composition containing acetylated hyaluronic acid and a pharmacologically acceptable carrier. Preferably, the average molecular weight of the acetylated hyaluronic acid is 10,000 to 1,000,000, and the acetyl group substitution number is from 2.0 to 4.0. In a preferred embodiment, this ophthalmic pharmaceutical composition is used in the treatment or prevention of dry eye, and in an even more preferred embodiment it is a dry-eye instillation.

Description

[0001] This application claims the priority of Japanese application No. 2003-051161 filed on 27th Feb. 2003, which is incorporated by reference. FIELD OF THE INVENTION [0002] The present invention relates to an ophthalmic pharmaceutical composition that contains acetylated hyaluronic acid and has excellent moisture retention. BACKGROUND OF ART [0003] The number of patients or pseudo-patients complaining of dry eye (dryness of the eyes) is expected to continue to climb as our society ages and as people increasingly strain their eyes by watching television and using office equipment such as word processors and personal computers. The cause of dry eye is a reduction in lacrimal quantity or a qualitative change in the components thereof, and this disorder can result in scratching or other damage when the surface of the eye becomes dry. Symptoms include eye pain or fatigue, increased blinking, and bloodshot eyes. Further, bacteria may enter through a scratch and cause infection, and if t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/728A61P27/02A61P27/04C08B37/08
CPCA61K31/728C08B37/0072A61P27/02A61P27/04C08B37/00
InventorUENO, NORIOOKA, TAKASHI
OwnerSHISEIDO CO LTD