Topical macqui berry formulation

Abstract

The present invention provides a topical formulation and method of use where the formulation comprises macqui berry or a macqui berry extract containing anthocyanins having a very high oxygen radical absorbance capacity (ORAC). The formulation provides the macqui berry in a stabilized form which includes a glucuronide or glycuronide, a photostabilizing agent, encapsulation, or light -and / or air-blocking packaging.

Description

[0001] This application claims priority pursuant to 35 U.S.C. §119 from Provisional Patent Application Ser. No. 60 / 719,530 filed Sep. 21, 2005, the entire disclosure of which is hereby incorporated by reference.FIELD OF THE INVENTION [0002] The present invention relates to the topical application of compositions containing macqui berry or macqui berry extract in a topical formulation for the prevention and / or treatment of damage to skin, particularly skin damage resulting from chronoaging and photoaging. BACKGROUND OF THE INVENTION [0003] Skin is subject to abuse by many extrinsic (environmental) factors as well as intrinsic factors. A common extrinsic factor is exposure to ultraviolet radiation. Whether extrinsic or intrinsic, the abuse results in skin aging. Skin aging happens in two ways: (1) through the natural aging process which dermatologists call chronological aging (also known as chronoaging); and (2) through UV rays in sunlight accelerating the aging process which dermatol...

AI Technical Summary

Benefits of technology

[0015] In one embodiment, in addition to the administration of topical composition containing macqui berry in a stabilized form to the skin, macqui berry is also orally administered on its own or together with other antioxidants and synergistic compounds disclosed herein that are suitable for oral administration. This increases the protective effect on the skin.

Problems solved by technology

Whether extrinsic or intrinsic, the abuse results in skin aging.

Chronoaging results in thinning, loss of elasticity and general degradation of skin.

There is also a flattening of the dermal-epidermal junction which results in weaker mechanical resistance.

However, there are problems associated with these and other uses of antioxidants in a topical formulation.

Particularly, antioxidants are readily oxidized and lose their anti-oxidant capacity.

Additionally, some of the oxidation products of antioxidants will have a deleterious effect; for example, vitamin C oxidizes to dehydroascorbate which is known to lead to the formation of advanced glycation endproducts (AGEs) and therefore increase the signs of aging skin.