Triterpene Compounds which are Effective on Improvement of Brain Function

a triterpene compound and brain technology, applied in the field of triterpene compounds, can solve the problems of cognitive impairment, social and economic loss, and serious social and economic problems, and achieve the effects of improving brain function, reducing the risk of death, and improving the effect of cognitive function

Inactive Publication Date: 2007-10-25
SK CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the percentage of elderly people in population increases over the world, various degenerative senile diseases and disorders have been drawing much of public attention by causing great loss both in social and economic points of view.
Dementia is a disease known very hard to cure and causes to devastate the life of its patient as well as to disrupt a life of his / her family, thereby leading to serious social and economical problems.
Moreover, mild cognitive impairment (MCI) as a pre-stage of dementia is characterized by a less cognitive function such as memory, perception and learning than normal aged people, being not consistent with the clinical standards of dementia.
Recent clinical studies have shown that patients with mild cognitive impairment are very susceptible to development of dementia.
However, the drug elicits adverse effects associated with liver so that its administration rarely performs.
However, both tacrine and aricept cannot treat Alzheimer's disease completely and their administration period and effective duration are not obvious.

Method used

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  • Triterpene Compounds which are Effective on Improvement of Brain Function
  • Triterpene Compounds which are Effective on Improvement of Brain Function
  • Triterpene Compounds which are Effective on Improvement of Brain Function

Examples

Experimental program
Comparison scheme
Effect test

examples

[0033] The following specific examples are intended to be illustrative of the invention and should not be construed as limiting the scope of the invention as defined by appended claims.

example1

Passive Avoidance Test

[0034] To verify whether oleanolic acid, hederagenine and ursolic acid may improve in vivo the failure of memory associated with mild cognitive impairment and dementia, the passive avoidance test was carried out.

[0035] A shuttle box (50×15×40 cm) was used as an experimental device. The box was divided into two rooms by a guillotine door, where one of which was bright by illumination while the other was dark by black cloth, giving rise to two different illumination effects.

[0036] Firstly, mice were placed into a bright room, the bright room was kept lighted and the guillotine door was kept open. The mice entered the dark room in 20 sec in accordance with their negative phototaxis and the guillotine door was kept closed upon the entrance. The latency period in which a mouse enters the dark room from the bright room was measured in a manner described above. On the first day of the test, all mice were subject to a training trial for 20-sec latency period.

[0037]...

example2

Toxicity Test

[0042] Oleanolic acid, hederagenine and ursolic acid were orally administered seven times into ICR mice (body weight 25-30 g, 5 male mice per unit dose, BGI, Korea) in the unit dose of 2.0 g / kg, 680 mg / kg, 230 mg / kg and 75 mg / kg, respectively, for 1 week and on that day, mice treated were observed with naked eyes in an interval of 30 min. Furthermore, for 2 weeks after the administration, the death rate, general conditions and body weight of mice were examined and abnormality of organs was observed via autopsy.

[0043] It was elucidated that LD50 of oleanolic acid, hederagenine and ursolic acid was no less than 5.0 g / kg (LD10=750 mg / kg), all dosages gave rise to no disorders and the results of autopsy were not different from the control group.

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Abstract

The present invention relates to the triterpene compounds improving in brain functions. In particular, the present invention relates to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory and a pharmaceutical composition for improving brain functions comprising the triterpene compounds represented by the Formula 1.

Description

BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention [0002] The present invention relates to triterpene compounds which can improve brain functions, in particular to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory and a pharmaceutical composition for improving brain functions comprising the triterpene compounds represented by the Formula 1. [0003] 2. Description of the Related Art [0004] As the percentage of elderly people in population increases over the world, various degenerative senile diseases and disorders have been drawing much of public attention by causing great loss both in social and economic points of view. According to recent results of statistical researches reported by the American Dementia Association and the National Aging Research Institute, four million Americans are suffering from dementia, which is generally developed after the age of sixty and sometimes developed even in fifties. 10.3% of Americans age...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/19A61P25/00A61P25/28A23L1/30A61K31/56
CPCA23L1/30A23V2002/00A61K31/56A23V2200/322A23V2250/2124A23V2250/214A23V2250/708A23V2250/712A23V2250/1592A23V2250/1642A23L33/10A61P25/00A61P25/28
Inventor CHOI, WONRACKHAN, CHANG-KYUNKIM, TAE KONIM, GUANG-JINJUNG, CHIL MANNYUN, SE JUNKIM, BONGCHEOLLEE, SOOMINKWAK, WIE-JONG
Owner SK CHEM CO LTD
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