Incorporation of biomolecules in thin films
a biomolecule and thin film technology, applied in the direction of fluid pressure measurement, peptides, liquid/fluent solid measurement, etc., can solve the problems of not being particularly satisfactory in the introduction of biomolecules in thin films
Inactive Publication Date: 2008-06-19
P J EDMONSON
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Benefits of technology
The present invention provides a method of incorporating biomolecules, such as antibodies and enzymes, into thin films for various applications such as biosensors and drug delivery systems. The method involves using an electrophoretic technique to cause the biomolecules to migrate from a medium into the thin film. The invention allows for better placement and retention of biomolecules within the thin film, and can also be used to modify the mechanical and physical properties of the thin film. The invention can be applied to various optical, micro mechanical system, and nano mechanical system devices.
Problems solved by technology
Various methods of incorporating biomolecules in thin films have previously been proposed, for example a plasma polymerization method and a spin casting method, but none have been particularly satisfactory.
Method used
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[0049]The acoustic wave is the dominant factor that determines detection sensitivity of an acoustic wave biosensor. The acoustic wave can be defined either as various derivations of bulk waves or surface waves, as described by C. K. Campbell, Surface Acoustic Wave Devices for Mobile and Wireless Communications, Academic Press, 1998. In general, the acoustic wave propagates through piezoelectric material and can generate changes in its properties (phase shift, velocity change, attenuation, etc.) that are caused by the interaction of the acoustic wave with target material embedded within a selective biolayer. Such changes in acoustic wave properties can be electrically transformed via the piezoelectric effect and metal structure into a detectable electrical signal. FIG. 1 is a cross-sectional view of the basic structure of an acoustic wave biosensor 100. The piezoelectric material 110 is chosen to support the required acoustic wave 115 to meet the application objective of the biosenso...
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Abstract
A method of incorporating biomolecules in a thin film mounted on a substrate, with the film having a thickness of not more than about 10 microns, includes providing a metal structure on the substrate between the thin film and the substrate, positioning a medium containing biomolecules in contact with a side of the film remote from the metal substrate, and applying a predetermined electrical voltage between the metal substrate and the medium to cause biomolecules to migrate in an electrophoretic manner from the medium into the thin film.
Description
FIELD OF INVENTION[0001]The present invention relates to the incorporation of biomolecules in a thin film, namely a film with a thickness of not more than about 10 microns.BACKGROUND OF THE INVENTION[0002]Various methods of incorporating biomolecules in thin films have previously been proposed, for example a plasma polymerization method and a spin casting method, but none have been particularly satisfactory. The plasma polymerization method and the spin casting method will be commented on in more detail later.[0003]It is an object of this invention to provide an improved method for incorporating biomolecules in thin films.SUMMARY OF THE INVENTION[0004]The present invention provides a method of incorporating biomolecules in a thin film mounted on a substrate, with the film having a thickness of not more than about 10 microns, said method including providing a metal structure on the substrate between the thin film and the substrate, positioning a medium containing biomolecules in cont...
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IPC IPC(8): C25D15/00
CPCC25D13/20C25D13/04
Inventor TAMIRISA, PRABHAKAR APPARAOLEE, SANG HUNHUNT, WILLIAM D.HESS, DENNIS WILLIAMEDMONSON, PETER J.
Owner P J EDMONSON