System and Method of Bladder and Sphincter Control

a sphincter and bladder technology, applied in the field of electric stimulation of the nervous system, can solve the problems of reduced efficiency of urine expulsion, loss of sensation and reflexes, and small reflex bladder contractions, and achieve the effect of reducing or eliminating the external urethral sphincter (eus) contractions and interferen

Inactive Publication Date: 2009-10-08
CASE WESTERN RESERVE UNIV
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  • Abstract
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Benefits of technology

[0007]In another aspect of the disclosure the system and method comprises coupling a first electrode to an intradural portion of a sacral dorsal root of a subject and coupling a second electrode to an intradural portion of a sacral ventral root of the subject. The system and method further comprises concurrently applying a first series of intermittent pulse tr

Problems solved by technology

The methods can suffer from the problem of contraction of the bladder to expel urine concurrently with contraction of the external urethral sphincter blocking urine flow.
The rhizotomy technique also results in the loss of sensation and

Method used

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  • System and Method of Bladder and Sphincter Control
  • System and Method of Bladder and Sphincter Control
  • System and Method of Bladder and Sphincter Control

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examples

[0052]Reference is now made to the following examples, which together with the above descriptions; illustrate the invention in a non-limiting fashion.

[0053]In one exemplary set of experiments that demonstrate an embodiment of the present system and method, a motor stimulus was applied to an animal having a spinal cord injury under 15 mg / kg α-chloralose anesthesia. The motor stimulus was applied to sensory dermatomes to affect the EUS in the animal. Referring to FIG. 9a, when only a motor stimulus 34 was applied, bladder contractions 35 and EUS contractions 36 occurred during the motor stimulus 34. After the motor stimulus 34 was terminated, undesirable reflex EUS contractions 37 occurred as seen between 35s and 55s on the x-axis. Referring to FIG. 9b, the use of a pulse bursting stimulus 38 applied on sensory dermatomes 21 in accordance with an aspect of the disclosure eliminated the undesirable reflex EUS contractions 37 of FIG. 9a. The best dermatome bursting patterns in these exp...

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Abstract

A method and system for bladder control are disclosed. In embodiments, a method for bladder control is provided that comprises coupling an electrode to an afferent nerve that is related to the bladder. Applying a plurality of pulse burst stimulations via the electrode causes voiding of urine from the bladder. In embodiments, the plurality of pulse burst stimulations to the afferent nerve reduces external urethral sphincter (EUS) contractions and evokes bladder contractions to expel urine from the subject. In embodiments, the plurality of pulse burst stimulations to the afferent nerve evokes bladder contractions alone to expel urine from the subject. In embodiments, a system for bladder control is provided that comprises an electrode for applying a pulse burst stimulus to an afferent nerve or dermatome to reduce reflex contractions and a signal generator for generating the pulse burst stimulus.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the benefit of U.S. Provisional Patent Ser. No. 61 / 041,753 filed Apr. 2, 2008, entitled “METHODS FOR BLADDER CONTROL,” the entire disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to electrical stimulation of the nervous system, and particularly relates to a system and method for urinary bladder and sphincter control utilizing electrical stimulation.BACKGROUND[0003]Retention of urine, leading to complications such as urinary tract infection and urinary calculi, remains a major factor leading to morbidity in individuals with neurologic disorders or injury such as spinal cord injury. In high cord injury, with upper motor neuron damage, the lower nerve pathways to the bladder are intact. The aim of micturition control in these individuals is to enable them to contract the bladder musculature without direct or reflex activation of structures in the ...

Claims

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Application Information

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IPC IPC(8): A61N1/36
CPCA61N1/36007
Inventor BHADRA, NARENDRAGUSTAFSON, KENNETH J.BRUNS, TIMOTHY M.MARIANO, TIMOTHY Y.
Owner CASE WESTERN RESERVE UNIV
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